摘要:藥物和個人護(hù)理用品（PPCPs）指各種香料、化妝品、遮光劑、染發(fā)劑、處方和非處方藥（包括人和動物用藥）等有機(jī)合成化學(xué)品的總稱，應(yīng)用非常廣泛。化學(xué)物質(zhì)的固有生物毒性決定了其在造福人類的同時也帶來環(huán)境和健康風(fēng)險，PPCPs已成為全球廣泛關(guān)注的新型污染物。在過去的十幾年內(nèi)，國際社會針對PPCPs來源、環(huán)境歸趨和對人類健康的風(fēng)險等進(jìn)行了大量的研究，我國PPCPs的生產(chǎn)和消費量巨大，面臨的污染情勢更加嚴(yán)峻。本文綜述了國內(nèi)外對PPCPs的研究進(jìn)展，提出了我國應(yīng)對PPCPs污染的對策建議。

Abstract:Pharmaceutical and personal care products (PPCPs) are a general term for a wide range of organic synthetic chemicals such as perfumes, cosmetics, sunscreens, hair dyes, prescription and nonprescription drugs (including human and veterinary drugs). The inherent biological toxicity of chemicals determines their environmental and health risks while benefiting humans, and PPCPs have become the new emerging pollutant garnered extensive attention of the international community. In the past ten years, the international community has conducted a lot of research on the sources, environmental fate, risks to human health of PPCPs. The production and consumption of PPCPs in China is huge, and the pollution situation is even more severe. This paper reviewed the domestic and international research progress of PPCPs, conducted research on the pollution of PPCPs in China, and proposed the countermeasures for PPCPs pollution control.

Daughton C G, Ternes T A. Pharmaceuticals and personal care products in the environment:Agents of subtle change?[J]. Environmental Health Perspectives, 1999, 107(6):907-938Liu J, Wong M H. Pharmaceuticals and personal care products (PPCPs):A review on environmental contamination in China[J]. Environment International, 2013, 182(1):208-224張芹, 張圣虎, 汪貞, 等. 駱馬湖表層水體中32種PPCPs類物質(zhì)的污染水平、分布特征及風(fēng)險評估[J]. 環(huán)境科學(xué), 2017, 38(1):162-169

Zhang Q, Zhang S H, Wang Z, et al. Pollution level, distribution characteristics and risk assessment of 32 PPCPs in surface water of Luomahu Lake[J]. Environmental Science, 2017, 38(1):162-169(in Chinese)

劉印平, 祝凌燕, 李敬光. 藥品與個人護(hù)理用品的生態(tài)與健康影響研究進(jìn)展[J]. 衛(wèi)生研究, 2009, 38(2):237-240

Liu Y P, Zhu L Y, Li J G. Research process of pharmaceutical and personal care products on ecological and human health[J]. Journal of Hygiene Research, 2009, 38(2):237-240(in Chinese)

Kolpin D W, Furlong E T, Meyer M T, et al. Pharmaceuticals, hormones, and other organic wastewater contaminants in U.S. streams, 1999-2000:A National Reconnaissance[J]. Environmental Science and Technology, 2002, 36(6):1202-1211Ramirez A J, Brain R A, Usenko S, et al. Occurrence of pharmaceuticals and personal care products (PPCPs) in fish tissues:Results of a national pilot study in the United States[J]. Environmental Toxicology and Chemistry, 2009, 28:2587-2597Monteiro S C, Boxall A B A. Factors affecting the degradation of pharmaceuticals in agricultural soils[J]. Environmental Toxicology & Chemistry, 2009, 28(12):2546-2554Center for Drug Evaluation and Research. Guidance for industry-environmental assessment of human drug and biologics applications[R]. Washington DC:United States Food & Drug Administration, 1998United States Environmental Protection Agency. Effluent guidelines-Pharmaceutical manufacturing effluent guidance documents[R]. Washington DC:United States Environmental Protection Agency, 1998代朝猛, 周雪飛, 張亞雷, 等. 環(huán)境介質(zhì)中藥物和個人護(hù)理品的潛在風(fēng)險研究進(jìn)展[J]. 環(huán)境污染與防治, 2009, 31(2):77-80

Dai C M, Zhou X F, Zhang Y L, et al. Research advancements in potential risk of PPCPs of environmental media[J]. Environmental Pollution and Control, 2009, 31(2):77-80(in Chinese)

胡洪營, 王超, 郭美婷. 藥品和個人護(hù)理用品(PPCPs)對環(huán)境的污染現(xiàn)狀與研究進(jìn)展[J]. 生態(tài)環(huán)境, 2005, 14(6):947-952

Hu H Y, Wang C, Guo M T. The present status of environmental pollution by pharmaceuticals and personal care products (PPCPs)[J]. Ecology and Environment, 2005, 14(6):947-952(in Chinese)

United States Environmental Protection Agency. Method 1694:Pharmaceuticals and personal care products in water, soil, sediment, and biosolids by HPLC/MS/MS[R]. Washington DC:United States Environmental Protection Agency, 2007United States Environmental Protection Agency. Contaminants of emerging concern (CECs) in fish:Pharmaceuticals and personal care products (PPCPs)[R]. Washington DC:United States Environmental Protection Agency, 2013European Agency for the Evaluation of Medicinal Products. Guideline on environmental impact assessment for veterinary medicinal products phase Ⅱ. CVMP/VICH/790/03-FINAL[R]. London:Committee for Medicinal Products for Veterinary Use, 2004European Medicines Agency. Guideline on the environmental risk assessment of medicinal products for human use. EMEA/CHMP/SWP/4447/00 corr 1[R]. London:Committee for Medicinal Products for Human Use, 2006Australia Department of Health. CTD Module 1 Administrative information and prescribing information for Australia[R]. Canberra:Therapeutic Goods Administration, 2018World Health Organization. Pharmaceuticals in drinking water[R]. Geneva:World Health Organization, 2011胡金龍. 典型PPCPs在污水處理廠中的遷移轉(zhuǎn)化規(guī)律研究[D]. 上海:東華大學(xué), 2014:3-6 Hu J L. Occurrence and removal of typical pharmaceuticals and personal care products (PPCPS) in a wastewater treatment plant[D]. Shanghai:Donghua University, 2014:3

-6(in Chinese)

Khetan S K, Collins T J. Human pharmaceuticals in the aquatic environment:A challenge to Green Chemistry[J]. Chemical Reviews, 2006, 107:2319-2364安婧, 周啟星. 藥品及個人護(hù)理用品(PPCPs)的污染來源、環(huán)境殘留及生態(tài)毒性[J]. 生態(tài)學(xué)雜志, 2009, 28(9):1878-1890

An J, Zhou Q X. Pollution sources, environmental residues, and ecological toxicity of pharmaceuticals and personal care products (PPCPs):A review[J]. Chinese Journal of Ecology, 2009, 28(9):1878-1890(in Chinese)

高艷蓬, 李桂英, 馬盛韜, 等. 合成麝香的研究新進(jìn)展與當(dāng)前挑戰(zhàn):從人體護(hù)理、環(huán)境污染到人體健康[J]. 化學(xué)進(jìn)展, 2017, 29(9):1082-1092

Gao Y P, Li G Y, Ma S T, et al. Research progress and challenge of synthetic musks:From personal care, environment pollution to human health[J]. Progress in Chemistry, 2017, 29(9):1082-1092(in Chinese)

Artola-Garicano E, Borkent I, Damen K, et al. Sorption kinetics and microbial biodegradation activity of hydrophobic chemicals in sewage sludge:Model and measurements based on free concentrations[J]. Environmental Science and Technology, 2003, 37(1):116-122Rimkus G, Rimkus B, Wolf M. Nitro musks in human adipose tissue and breast milk[J]. Chemosphere, 1994, 28(2):421-432Sanderson H, Dyer S D, Price B B, et al. Occurrence and weight-of-evidence risk assessment of alkyl sulfates, alkyl ethoxysulfates, and linear alkylbenzene sulfonates (LAS) in river water and sediments[J]. Science of the Total Environment, 2006, 368(2):695-712薩仁其其格. 內(nèi)蒙古牧區(qū)土壤中鏈霉素殘留的檢測及吸附行為的研究[D]. 呼和浩特:內(nèi)蒙古大學(xué), 2010:2 Sarenqiqige. Study on detection of streptomycin residue and adsorption behavior on soil of Inner Mongolia pastoral[D]. Hohhot:Inner Mongolia University, 2010:2(in Chinese)萬遂如. 關(guān)于我國畜牧業(yè)生產(chǎn)中限制抗生素的使用問題[J]. 養(yǎng)豬, 2017(1):1-5應(yīng)光國. 中國抗生素使用與流域污染[C]//中國化學(xué)會. 中國化學(xué)會第30屆學(xué)術(shù)年會摘要集-第二十六分會:環(huán)境化學(xué). 大連:中國化學(xué)會, 2016:1周靜. 日用化學(xué)品用合成麝香[J]. 日用化學(xué)工業(yè), 2016, 46(9):530-538

Zhou J. Synthetic musk in daily chemicals[J]. China Surfactant Detergent & Cosmetics, 2016, 46(9):530-538(in Chinese)

趙永杰. 2018年中國化妝品行業(yè)運行情況分析[J]. 日用化學(xué)品科學(xué), 2019, 42(9):1-5

Zhao Y J. Analysis on the operation of China cosmetic industry in 2018[J]. Detergent & Cosmetics, 2019, 42(9):1-5(in Chinese)

Kang X, Bhandari A, Das K, et al. Occurrence and fate of pharmaceuticals and personal care products (PPCPs) in biosolids[J]. Journal of Environment Quality, 2005, 34(1):91-104劉學(xué)婭, 趙亞洲, 冷平生. 城市污泥的土地利用及其環(huán)境影響研究進(jìn)展[J]. 農(nóng)學(xué)學(xué)報, 2018, 8(6):21-27

Liu X Y, Zhao Y Z, Leng P S. Land use of municipal sludge and its environmental impacts:Research progress[J]. Journal of Agriculture, 2018, 8(6):21-27(in Chinese)

熊云武, 林曉燕, 龔亞龍, 等. 城市污泥安全農(nóng)用研究進(jìn)展[J]. 現(xiàn)代農(nóng)業(yè)科技, 2016(3):228-229 Xiong Y W, Lin X Y, Gong Y L, et al. Research advance on safe utilization of municipal sewage sludge as agricultural resource[J]. Modern Agricultural Science and Technology, 2016

(3):228-229(in Chinese)

李彥文, 莫測輝, 趙娜, 等. 菜地土壤中磺胺類和四環(huán)素類抗生素污染特征研究[J]. 環(huán)境科學(xué), 2009, 30(6):1762-1766

Li Y W, Mo C H, Zhao N, et al. Investigation of sulfonamides and tetracyclines antibiotics in soil from various vegetable fields[J]. Environmental Science, 2009, 30(6):1762-1766(in Chinese)

田藝心, 王美娥, 陳衛(wèi)平, 等. 污水和污泥中的人工合成麝香分析方法[J]. 生態(tài)學(xué)雜志, 2011, 30(2):395-400

Tian Y X, Wang M E, Chen W P, et al. Analytical methods for synthetic musk in wastewater and sewage sludge[J]. Chinese Journal of Ecology, 2011, 30(2):395-400(in Chinese)

Peng X Z, Yu Y Y, Tang C M, et al. Occurrence of steroid estrogens, endocrine-disrupting phenols, and acid pharmaceutical residues in urban riverine water of the Pearl River Delta, South China[J]. Science of the Total Environment, 2008, 397(1-3):158-166

相關(guān)知識

中國水污染的轉(zhuǎn)型特征與政策建議
全球水污染現(xiàn)狀以及中國水污染現(xiàn)狀
淺議我國電磁輻射污染防治的對策.doc
土壤污染防治難點及對策研究
環(huán)境污染及其治理對策
明確目標(biāo)和舉措，持續(xù)開展新污染物治理及風(fēng)險防控
乳及乳制品中微生物污染及其控制研究
我國土壤污染防治現(xiàn)狀分析及未來路徑研究
中華人民共和國土壤污染防治法
中華人民共和國水污染防治法

網(wǎng)址: 中國藥物和個人護(hù)理用品污染現(xiàn)狀及管控對策建議 http://m.u1s5d6.cn/newsview241174.html