運(yùn)動(dòng)干預(yù)對(duì)睡眠障礙的影響及作用機(jī)制研究進(jìn)展
摘要:
睡眠障礙嚴(yán)重影響人們的身心健康,已成為現(xiàn)代社會(huì)人們普遍關(guān)注的問(wèn)題。研究表明,急性運(yùn)動(dòng)干預(yù)和長(zhǎng)期規(guī)律性運(yùn)動(dòng)干預(yù)均可改善紊亂的睡眠結(jié)構(gòu),使各期睡眠時(shí)長(zhǎng)和比例趨于正常。運(yùn)動(dòng)干預(yù)還能對(duì)睡眠期間的內(nèi)分泌功能、代謝功能、免疫應(yīng)答、自主神經(jīng)系統(tǒng)和心臟功能產(chǎn)生積極影響,是改善睡眠障礙的一種非藥物治療手段。運(yùn)動(dòng)干預(yù)的類型(有氧運(yùn)動(dòng)、抗阻運(yùn)動(dòng)、身心運(yùn)動(dòng))是運(yùn)動(dòng)干預(yù)方案的調(diào)節(jié)變量之一,不同類型的運(yùn)動(dòng)改善睡眠障礙的機(jī)制存在差異。運(yùn)動(dòng)量、運(yùn)動(dòng)強(qiáng)度是運(yùn)動(dòng)干預(yù)方案的另一調(diào)節(jié)變量,針對(duì)個(gè)體可能存在改善睡眠障礙最佳的運(yùn)動(dòng)量和運(yùn)動(dòng)強(qiáng)度。在不同時(shí)間段實(shí)施的運(yùn)動(dòng)干預(yù)也會(huì)對(duì)睡眠障礙造成不同程度的影響,目前在改善睡眠質(zhì)量最佳運(yùn)動(dòng)時(shí)間段方面尚未形成共識(shí)。本文從表觀遺傳、過(guò)度覺(jué)醒、晝夜節(jié)律、體溫調(diào)節(jié)等4個(gè)方面總結(jié)了運(yùn)動(dòng)改善睡眠障礙的作用機(jī)制,并討論了目前該領(lǐng)域的研究不足和研究展望,為睡眠障礙運(yùn)動(dòng)處方的制定提供理論依據(jù)。
關(guān)鍵詞: 運(yùn)動(dòng)干預(yù) / 睡眠障礙 / 機(jī)制 / 綜述Abstract:
Sleep disorders, a common concern in modern society, seriously affect people's physical and mental health. Reported findings suggest that both acute exercise intervention and long-term regular exercise intervention can improve the disrupted sleep structure and normalize the duration and proportion of the different phases of sleep. Moreover, exercise intervention has a positive effect on the endocrine functions, the metabolic functions, the immune response, the autonomic nervous system, and cardiac functions during sleep. It is a non-medicative therapeutic strategy for improving sleep disorders. The specific type of exercise intervention (aerobic exercise, resistance exercise, or meditative movement) adopted is one of the moderating variables of exercise intervention programs. Different types of exercise improve sleep disorders by way of different mechanisms. Exercise volume and intensity are another moderating variable of exercise intervention programs. The optimal amount and intensity of exercise for different individuals to improve sleep disorders may vary. Exercise interventions implemented at the different times throughout a day can also have varying degrees of impact on sleep disorders and there is no consensus on the optimal exercise time for improving sleep quality at present. Herein, we summarized the mechanisms by which exercise intervention improves sleep disorders from four perspectives, including epigenetics, hyperarousal, human circadian rhythm, and body temperature regulation. In addition, we discussed the current gaps and prospects of research in this field, aiming to provide a theoretical basis for the development of exercise prescriptions for sleep disorders.
[1] 任志洪, 謝菲, 余香蓮, 等. 失眠的自助式認(rèn)知行為治療元分析: 療效、影響因素及證據(jù)評(píng)價(jià). 心理科學(xué)進(jìn)展,2016,24(2): 173–195. doi: 10.3724/SP.J.1042.2016.00173.REN Z H, XIE F, YU X L, et al. A meta-analysis of self-help cognitive behavioral therapy for insomnia: Efficacy, influential factors and the quality of evidence. Adv Psychol Sci,2016,24(2): 173–195. doi: 10.3724/SP.J.1042.2016.00173.
[2] 王俊秀, 張衍, 張躍, 等. 中國(guó)睡眠研究報(bào)告2023. 北京: 社會(huì)科學(xué)文獻(xiàn)出版社, 2023: 13-33.WANG J X, ZHANG Y, ZHANG Y, et al. Chinese Sleep Research Report 2023. Beijing: Social Sciences Academic Press, 2023: 13–33.
[3]SO B C L, KWOK S C, LEE P H. Effect of aquatic exercise on sleep efficiency of adults with chronic musculoskeletal pain. J Phys Act Health,2021,18(9): 1037–1045. doi: 10.1123/jpah.2020-0476.
[4]Da SILVA R P, MARTINEZ D, URIBE RAMOS J M, et al. The effects of resistance exercise on obstructive sleep apnea severity and body water content in older adults: a randomized controlled trial. Sleep Med,2022,95(8): 37–46. doi: 10.1016/j.sleep.2022.04.014.
[5]HASAN F, TU YK, LIN C M, et al. Comparative efficacy of exercise regimens on sleep quality in older adults: a systematic review and network meta-analysis. Sleep Med Rev,2022,27(65): 1–7. doi: 10.1016/j.smrv.2022.101673.
[6] 李國(guó)平, 王正珍, 郝躍峰, 等. 運(yùn)動(dòng)處方中國(guó)專家共識(shí)(2023). 中國(guó)運(yùn)動(dòng)醫(yī)學(xué)雜志,2023,42(1): 3–13. doi: 10.16038/j.1000-6710.2023.01.012.LI G P, WANG Z Z, HAO Y F, et al. Chinese Expert Consensus on Exercise Prescription (2023). Chin J Sports Med,2023,42(1): 3–13. doi: 10.16038/j.1000-6710.2023.01.012.
[7]CHENNAOUI M, ARNAL P J, SAUVET F, et al. Sleep and exercise: a reciprocal issue. Sleep Med Rev,2015,20(4): 59–72. doi: 10.1016/j.smrv.2014.06.008.
[8] 王寶森, 李婷文. 不同運(yùn)動(dòng)形式對(duì)老年人睡眠質(zhì)量的影響. 中國(guó)老年學(xué)雜志,2020,40(7): 1465–1469. doi: 10.3969/j.issn.1005-9202.2020.07.037.WANG B S, LI T W. Effect of different exercise forms on sleep quality of the elderly. Chin J Gerontol,2020,40(7): 1465–1469. doi: 10.3969/j.issn.1005-9202.2020.07.037.
[9]KALAK N, GERBER M, KIROV R, et al. Daily morning running for 3 weeks improved sleep and psychological functioning in healthy adolescents compared with controls. Adolesc Health,2012,51(6): 615–622. doi: 10.1016/j.jadohealth.2012.02.020.
[10]BLANCO-CENTURION C A, SHIROMANI P J. Beneficial effects of regular exercise on sleep in old F344 rats. Neurobiol Aging,2006,27(12): 1859–1869. doi: 10.1016/j.neurobiolaging.2005.10.009.
[11] 胡亮, 韓雨晴. 運(yùn)動(dòng)抗抑郁的神經(jīng)生物學(xué)機(jī)制研究新進(jìn)展. 陜西師范大學(xué)學(xué)報(bào)(自然科學(xué)版),2019,47(3): 9–20. doi: 10.15983/j.cnki.jsnu.2019.03.232.HU L, HAN Y Q. Research progress on the neurobiological mechanism of the antidepressant effects of exercise. J Shanxi Norm Univ (Nat Sci Edit),2019,47(3): 9–20. doi: 10.15983/j.cnki.jsnu.2019.03.232.
[12]TUCKOW A P, RARICK K R, KRAEMER W J, et al. Nocturnal growth hormone secretory dynamics are altered after resistance exercise: deconvolution analysis of 12-hour immunofunctional and immunoreactive isoforms. Am J Physiol Regul Integr Comp Physiol,2006,291(6): 1749–1755. doi: 10.1152/ajpregu.00854.2005.
[13]CREWTHER B T, COOK C, CARDINALE M, et al. Two emerging concepts for elite athletes: the short-term effects of testosterone and cortisol on the neuromuscular system and the dose-response training role of these endogenous hormones. Sports Med,2011,41(2): 103–123. doi: 10.2165/11539170-000000000-00000.
[14]CHEN P, BAYLIN A, LEE J, et al. The association between sleep duration and sleep timing and insulin resistance among adolescents in Mexico City. J Adolesc Health,2021,69(1): 57–63. doi: 10.1016/j.jadohealth.2020.10.012.
[15]FENTON S, BURROWS T L, COLLINS C E, et al. Efficacy of a multi-component m-health diet, physical activity, and sleep intervention on dietary intake in adults with overweight and obesity: a randomised controlled trial. Nutrients,2021,13(7): 1–17. doi: 10.3390/nu13072468.
[16] 岳宇嬌, 徐平. 睡眠剝奪相關(guān)血液生物學(xué)指標(biāo)研究進(jìn)展. 中國(guó)神經(jīng)精神疾病雜志,2020,46(6): 376–379. doi: 10.3969/j.issn.1002-0152.2020.06.015.YUE Y J, XU P. Research progress on blood biological indicators related to sleep deprivation. Chin J Nerv Ment Dis,2020,46(6): 376–379. doi: 10.3969/j.issn.1002-0152.2020.06.015.
[17]SANTOS R V, TUFIK S, De MELLO M T. Exercise, sleep and cytokines: is there a relation. Sleep Med Rev,2007,11(3): 231–239. doi: 10.1016/j.smrv.2007.03.003.
[18]SCHEFFER D D L, LATINI A. Exercise-induced immune system response: anti-inflammatory status on peripheral and central organs. Biochim Biophys Acta Mol Basis Dis,2020,1866(10): 1–15. doi: 10.1016/j.bbadis.2020.165823.
[19]SHAW D M, MERIEN F, BRAAKHUIS A, et al. T-cells and their cytokine production: the anti-inflammatory and immunosuppressive effects of strenuous exercise. Cytokine,2018,104(3): 136–142. doi: 10.1016/j.cyto.2017.10.001.
[20] 張震, 王冬慧, 孫娜, 等. 失眠伴焦慮患者的腦功能及心率變異性分析. 首都醫(yī)科大學(xué)學(xué)報(bào),2021,42(3): 464–469. doi: 10.3969/j.issn.1006-7795.2021.03.021.ZHAGN Z, WANG D H, SUN N, et al. Analysis of brain function and heart rate variability in insomnia patients with anxiety. J Cap Med Univ,2021,42(3): 464–469. doi: 10.3969/j.issn.1006-7795.2021.03.021.
[21]KING A C, PRUITT L A, WOO S, et al. Effects of moderate-intensity exercise on polysomnographic and subjective sleep quality in older adults with mild to moderate sleep complaints. J Gerontol A Biol Sci Med Sci,2008,63(9): 997–1004. doi: 10.1093/gerona/63.9.997.
[22]RUBIO-ARIAS J á, MARíN-CASCALES E, RAMOS-CAMPO D J, et al. Effect of exercise on sleep quality and insomnia in middle-aged women: a systematic review and meta-analysis of randomized controlled trials. Maturitas,2017,100(1): 49–56. doi: 10.1016/j.maturitas.2017.04.003.
[23] 李瑩雪, 葛義俊, 孔曉藝, 等. 慢性失眠患者血清神經(jīng)營(yíng)養(yǎng)因子改變及其與睡眠質(zhì)量和認(rèn)知功能的關(guān)系. 中華神經(jīng)科雜志,2020,53(2): 85–90. doi: 10.3760/cma.j.issn.1006-7876.2020.02.002.LI Y X, GE Y J, SUN X Y, et al. Changed serum levels of neurotrophic factors and their correlations with sleep and cognition in patients with chronic insomnia disorder. Chin J Psychiatry,2020,53(2): 85–90. doi: 10.3760/cma.j.issn.1006-7876.2020.02.002.
[24]WHITWORTH J W, NOSRAT S, SANTABARBARA N J, et al. High intensity resistance training improves sleep quality and anxiety in individuals who screen positive for posttraumatic stress disorder: a randomized controlled feasibility trial. Ment Health Phys Act,2019,16(3): 43–49. doi: 10.1016/j.mhpa.2019.04.001.
[25]SANER N J, BISHOP D J, BARTLETT J D. Is exercise a viable therapeutic intervention to mitigate mitochondrial dysfunction and insulin resistance induced by sleep loss. Sleep Med Rev,2018,37(1): 60–68. doi: 10.1016/j.smrv.2017.01.001.
[26]SEVERINSEN M C K, PEDERSEN B K. Muscle-organ crosstalk: the emerging roles of myokines. Endocr Rev,2020,41(4): 594–609. doi: 10.1210/endrev/bnaa016.
[27]IRWIN M R, OLMSTEAD R, CARRILLO C, et al. Cognitive behavioral therapy vs. Tai Chi for late life insomnia and inflammatory risk: a randomized controlled comparative efficacy trial. Sleep,2014,37(9): 1543–1552. doi: 10.5665/sleep.4008.
[28]WANG F, EUN-KYOUNG LEE O, FENG F, et al. The effect of meditative movement on sleep quality: a systematic review. Sleep Med Rev,2016,30(12): 43–52. doi: 10.1016/j.smrv.2015.12.001.
[29] 王駿昇, 孟皎, 郭子肈, 等. 身心鍛煉對(duì)睡眠質(zhì)量影響的系統(tǒng)綜述. 中國(guó)康復(fù)理論與實(shí)踐,2023,29(2): 205–213. doi: 10.3969/j.issn.1006-9771.2023.02.009.WANG J S, MENG J, GUO Z Z, et al. Effects of mind-body exercise on sleep quality: a systematic review. Chin J Rehabil Theory Pract,2023,29(2): 205–213. doi: 10.3969/j.issn.1006-9771.2023.02.009.
[30] 侯江濤, 鄭鴻銘, 嚴(yán)梓萁, 等. 八段錦干預(yù)失眠癥患者療效的Meta分析. 廣州體育學(xué)院學(xué)報(bào),2022,42(2): 59–69. doi: 10.13830/j.cnki.cn44-1129/g8.2022.02.008.HOU J T, ZHENG H M, YAN Z Q, et al. Meta-analysis of the efficacy of baduanjin exercise on patients with sleep initiation and maintenance disorders. J Guangzhou Sport Univ,2022,42(2): 59–69. doi: 10.13830/j.cnki.cn44-1129/g8.2022.02.008.
[31] 李良, 曹烴, 鐘建偉, 等. 《美國(guó)人身體活動(dòng)指南第2版(2018)》解讀及啟示. 體育學(xué)刊,2019,26(5): 96–102. doi: 10.16237/j.cnki.cn44-1404/g8.2019.05.011.LI L, CAO T, ZHONG J W, et al. An interpretation of and inspirations from the American Physical Activity Guide 2nd Edition (2018). J Phys Educ,2019,26(5): 96–102. doi: 10.16237/j.cnki.cn44-1404/g8.2019.05.011.
[32]AN K Y, MORIELLI A R, KANG D W, et al. Effects of exercise dose and type during breast cancer chemotherapy on longer-term patient-reported outcomes and health-related fitness: a randomized controlled trial. Int J Cancer,2020,146(1): 150–160. doi: 10.1002/ijc.32493.
[33] 李振瑞, 占超, 郭超陽(yáng), 等. 預(yù)防老年人跌倒的最佳太極拳運(yùn)動(dòng)量的Meta分析. 時(shí)珍國(guó)醫(yī)國(guó)藥,2021,32(2): 504–509. doi: 10.3969/j.issn.1008-0805.2021.02.75.LI Z R, ZHAN C, GUO C Y, et al. Meta analysis of the optimal amount of Tai Chi exercise for preventing falls in the elderly. Lishizhen Med Mater Med Res,2021,32(2): 504–509. doi: 10.3969/j.issn.1008-0805.2021.02.75.
[34]KLINE C E, SUI X, HALL M H, et al. Dose-response effects of exercise training on the subjective sleep quality of postmenopausal women: exploratory analyses of a randomised controlled trial. BMJ Open,2012,2(4): 1–9. doi: 10.1136/bmjopen-2012-001044.
[35]BUMAN M P, KING A C. Exercise as a treatment to enhance sleep. Am J Lifestyle Med,2010,4(6): 500–514. doi: 10.1177/1559827610375532.
[36]STUTZ J, EIHOLZER R, SPENGLER C M. Effects of evening exercise on sleep in healthy participants: a systematic review and meta-analysis. Sports Med,2019,49(2): 269–287. doi: 10.1007/s40279-018-1015-0.
[37]BENLOUCIF S, ORBETA L, ORTIZ R, et al. Morning or evening activity improves neuropsychological performance and subjective sleep quality in older adults. Sleep,2004,27(1): 1542–1551. doi: 10.1093/sleep/27.8.1542.
[38]FRIMPONG E, MOGRASS M, ZVIONOW T, et al. The effects of evening high-intensity exercise on sleep in healthy adults: a systematic review and meta-analysis. Sleep Med Rev,2021,60(5): 1–16. doi: 10.1016/j.smrv.2021.101535.
[39] 石海旺, 李婕, 吳沖云, 等. 運(yùn)動(dòng)改善藥物依賴者免疫功能障礙的研究進(jìn)展. 中國(guó)體育科技,2021,57(6): 38–45. doi: 10.16470/j.csst.2021059.SHI H W, LI J, WU C Y, et al. Research on improving immune dysfunction in drug-dependent patients by exercise. China Sport Sci Technol,2021,57(6): 38–45. doi: 10.16470/j.csst.2021059.
[40]YUE T, LIU X, GAO Q, et al. Different intensities of evening exercise on sleep in healthy adults: a systematic review and network meta-analysis. Nat Sci Sleep,2022,14(14): 2157–2177. doi: 10.2147/NSS.S388863.
[41]CORTESE R. Epigenetics of sleep disorders: an emerging field in diagnosis and therapeutics. Diagnostics (Basel),2021,11(5): 1–4. doi: 10.3390/diagnostics11050851.
[42]CEDERNAES J, SCHONKE M, WESTHOLM J O, et al. Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans. Sci Adv,2018,4(8): 1–15. doi: 10.1126/sciadv.aar8590.
[43]PALAGINI L, GEOFFROY P A, GEHRMAN P R, et al. Potential genetic and epigenetic mechanisms in insomnia: a systematic review. J Sleep Res,2023,32(6): 13868–13878. doi: 10.1111/jsr.13868.
[44]PALAGINI L, BIBER K, RIEMANN D. The genetics of insomnia-evidence for epigenetic mechanisms. Sleep Med Rev,2014,18(3): 225–235. doi: 10.1016/j.smrv.2013.05.002.
[45]BONNET M H, ARAND D L. Hyperarousal and insomnia: state of the science. Sleep Med Rev,2010,14(1): 9–15. doi: 10.1016/j.smrv.2009.05.002.
[46]Van SOMEREN E J W. Brain mechanisms of insomnia: new perspectives on causes and consequences. Physiol Rev,2021,101(3): 995–1046. doi: 10.1152/physrev.00046.2019.
[47] 趙文瑞, 李陳渝, 陳軍君, 等. 失眠障礙與過(guò)度覺(jué)醒: 來(lái)自靜息態(tài)腦電和睡眠腦電的證據(jù). 中國(guó)科學(xué):生命科學(xué),2020,50(3): 270–286. doi: 10.1360/SSV-2019-0234.ZHAO W R, LI C Y, CHEN J J, et al. Insomnia disorder and hyperarousal: evidence from resting-state and sleeping EEG. Sci Sin Vitae,2020,50(3): 270–286. doi: 10.1360/SSV-2019-0234.
[48] 楊棟. 2種不同運(yùn)動(dòng)方式對(duì)原發(fā)性失眠患者睡眠質(zhì)量的干預(yù)效果. 上海體育學(xué)院學(xué)報(bào),2020,44(11): 38–43. doi: 10.16099/j.sus.2020.11.005.YNAG D. Intervention Effect of Two Different Exercise Modes on Sleep Ouality of Patients with Primary Insomnia. J Shanghai Univ Sport,2020,44(11): 38–43. doi: 10.16099/j.sus.2020.11.005.
[49]MEYER N, HARVEY A G, LOCKLEY S W, et al. Circadian rhythms and disorders of the timing of sleep. Lancet,2022,400(10357): 1061–1078. doi: 10.1016/S0140-6736(22)00877-7.
[50] 彭景, 任保印, 張荷等. 生物鐘紊亂防治策略的研究進(jìn)展. 生理學(xué)報(bào),2023,75(2): 279–290. doi: 10.13294/j.aps.2023.0021.PENG J, REN B Y, ZHANG H, et al. Research progress in control strategies of biological clock disorder. Acta Physiologica Sinica,2023,75(2): 279–290. doi: 10.13294/j.aps.2023.0021.
[51] 黃卓淳, 漆正堂, 劉微娜. 運(yùn)動(dòng)與褪黑素抗抑郁的作用、機(jī)制以及聯(lián)合策略研究進(jìn)展. 中國(guó)體育科技,2020,56(2): 3–14. doi: 10.16470/j.csst.2019085.HUANG Z C, QI Z T, LIU W N. Research progress on the antidepressant effect, mechanism and joint strategy of exercise and melatonin. China Sport Sci Technol,2020,56(2): 3–14. doi: 10.16470/j.csst.2019085.
[52] 劉恒旭, 陳佩杰, 盧文云, 等. 體育鍛煉: 介導(dǎo)骨骼肌晝夜節(jié)律分子鐘的時(shí)間線索. 上海體育學(xué)院學(xué)報(bào),2022,46(6): 94–106. doi: 10.16099/j.sus.2021.04.30.0002.LIU H X, CHEN P J, LU W Y, et al. Physical exercise: the time clue that mediates the molecular clock of skeletal muscle circadian rhythm. J Shanghai Univ Sport,2022,46(6): 94–106. doi: 10.16099/j.sus.2021.04.30.0002.
[53]REID K J, KR?UCHI K, GRIMALDI D, et al. Effects of manipulating body temperature on sleep in postmenopausal women. Sleep Med,2021,81(5): 109–115. doi: 10.1016/j.sleep.2021.01.064.
[54]LACK L C, GRADISAR M, Van SOMEREN E J, et al. The relationship between insomnia and body temperatures. Sleep Med Rev,2008,12(4): 307–317. doi: 10.1016/j.smrv.2008.02.003.
[55]MURPHY P J, CAMPBELL S S. Sex hormones, sleep, and core body temperature in older postmenopausal women. Sleep,2007,30(12): 1788–1794. doi: 10.1093/sleep/30.12.1788.
相關(guān)知識(shí)
豐富環(huán)境改善睡眠與認(rèn)知障礙的作用及研究進(jìn)展
孕婦睡眠障礙的影響因素研究
眩暈與睡眠障礙的研究進(jìn)展
孕期睡眠障礙的流行病學(xué)研究進(jìn)展
瑜伽對(duì)產(chǎn)前抑郁癥干預(yù)作用及機(jī)制的研究進(jìn)展
孕中期孕婦睡眠質(zhì)量現(xiàn)狀及影響因素研究進(jìn)展
孕期睡眠相關(guān)營(yíng)養(yǎng)因素的研究進(jìn)展
健康|研究顯示:廣東省睡眠障礙患病率高于全國(guó)
睡眠障礙
睡眠影響大腦健康
網(wǎng)址: 運(yùn)動(dòng)干預(yù)對(duì)睡眠障礙的影響及作用機(jī)制研究進(jìn)展 http://m.u1s5d6.cn/newsview532294.html
推薦資訊
- 1發(fā)朋友圈對(duì)老公徹底失望的心情 12775
- 2BMI體重指數(shù)計(jì)算公式是什么 11235
- 3補(bǔ)腎吃什么 補(bǔ)腎最佳食物推薦 11199
- 4性生活姿勢(shì)有哪些 盤點(diǎn)夫妻性 10425
- 5BMI正常值范圍一般是多少? 10137
- 6在線基礎(chǔ)代謝率(BMR)計(jì)算 9652
- 7一邊做飯一邊躁狂怎么辦 9138
- 8從出汗看健康 出汗透露你的健 9063
- 9早上怎么喝水最健康? 8613
- 10五大原因危害女性健康 如何保 7826
- 西鈺休閑食品加盟 費(fèi)用 代理?xiàng)l件 招商電
- 線上研討助力居家心育 ——臨沂西郊實(shí)驗(yàn)學(xué)
- 科學(xué)防疫,“宅”趣無(wú)窮——西溪學(xué)??茖W(xué)科
- 玉淵潭中學(xué)居家學(xué)習(xí)健康小貼士
- 有哪些休閑游戲 放松身心的好選擇
- plus會(huì)員:美的(Midea) 10K
- PLUS會(huì)員、需搶券:LittleSwa
- plus會(huì)員:海爾(Haier)全自動(dòng)8
- 再降價(jià)、PLUS會(huì)員:LittleSwa
- 無(wú)縫連接健康服務(wù)!探索日照首個(gè)居家醫(yī)養(yǎng)云