首頁(yè) 資訊趙曉

趙曉

來(lái)源：泰然健康網(wǎng) 時(shí)間：2024年12月03日 12:41

趙曉教授、博士生導(dǎo)師

陜西省三秦英才引進(jìn)人才青年項(xiàng)目

西安交通大學(xué)“青年拔尖人才A類”

西安交通大學(xué)青年創(chuàng)新團(tuán)隊(duì)骨干

中國(guó)生物化學(xué)與分子生物學(xué)會(huì)代謝專業(yè)分會(huì)青年委員

西安交通大學(xué)/醫(yī)學(xué)部/第一附屬醫(yī)院/Med-X研究院/免疫代謝性疾病研究所

本課題組長(zhǎng)期致力于研究組織器官間交流對(duì)話（Inter-organ communication）調(diào)控免疫代謝穩(wěn)態(tài)（Immune-metabolic homeostasis）的時(shí)空交互機(jī)制，探索能量穩(wěn)態(tài)的應(yīng)激響應(yīng)系統(tǒng)調(diào)控肥胖、衰老以及免疫代謝相關(guān)健康穩(wěn)態(tài)的分子機(jī)理，目前已鑒定了肌肉分泌因子、線粒體代謝物及脂滴等能量感應(yīng)因子，揭示了骨骼肌介導(dǎo)各組織器官協(xié)同響應(yīng)感染、晝夜節(jié)律或營(yíng)養(yǎng)應(yīng)激的能量轉(zhuǎn)換機(jī)制，發(fā)現(xiàn)了骨骼肌為核心的免疫代謝響應(yīng)體系，突破了組織器官間的免疫代謝對(duì)話如何適應(yīng)各種應(yīng)激的難題，為研究免疫代謝紊亂相關(guān)的疾病提供了理論基礎(chǔ)，共已發(fā)表SCI論文25篇，總計(jì)引用超過(guò)1000次，其中以第一作者發(fā)表SCI論文10篇，文章發(fā)表在Cell Metabolism，Current Biology，Aging Cell，Current Opinion in Insect Science，BMC Genomics等領(lǐng)域內(nèi)權(quán)威或Top期刊；單篇最高引用160多次，h指數(shù)14。相關(guān)研究引起了國(guó)內(nèi)外學(xué)者的廣泛關(guān)注和認(rèn)可，英國(guó)醫(yī)學(xué)科學(xué)院院士Irene Miguel-Aliaga教授為Cell Metabolism文章撰寫亮點(diǎn)評(píng)論文章，另外發(fā)表在Cell Metabolism和Current Biology的文章獲得Faculty Opinions（F1000Prime）推薦。曾主持完成國(guó)家自然科學(xué)基金青年項(xiàng)目（31301951）、中國(guó)博士后面上基金（2013M531638）各一項(xiàng)。目前正在受到西安交通大學(xué) “青年拔尖人才支持計(jì)劃”A類（2022-2028）、陜西省“三秦英才引進(jìn)人才”青年項(xiàng)目和國(guó)家自然科學(xué)基金面上項(xiàng)目（2023-2026）的支持。

電子郵箱:xiaozhao@xjtu.edu.cn 或 xzhao0228@gmail.com

聯(lián)系電話:19829837917

個(gè)人主頁(yè):https://gr.xjtu.edu.cn/web/1100012347

聯(lián)系地址:陜西省西安市西安交通大學(xué)創(chuàng)新港校區(qū)21號(hào)樓2018室

研究方向

營(yíng)養(yǎng)及能量代謝的穩(wěn)態(tài)調(diào)控是動(dòng)物應(yīng)對(duì)自然界各種生存挑戰(zhàn)的關(guān)鍵機(jī)制，動(dòng)物需要根據(jù)進(jìn)食狀態(tài)、營(yíng)養(yǎng)水平或病菌感染的動(dòng)態(tài)變化，利用免疫代謝感應(yīng)系統(tǒng)實(shí)時(shí)調(diào)整能量資源的攝取、儲(chǔ)存和利用。因此，能量代謝系統(tǒng)和天然免疫系統(tǒng)之間相互交叉，共進(jìn)化形成了復(fù)雜的免疫代謝交互網(wǎng)絡(luò)，在不同營(yíng)養(yǎng)、生理與病理應(yīng)激下調(diào)控能量代謝的適應(yīng)性改變，是維持系統(tǒng)性免疫代謝穩(wěn)態(tài)（immune-metabolic homeostasis）的關(guān)鍵機(jī)制。然而，各種營(yíng)養(yǎng)、飲食、生理與病理應(yīng)激往往誘發(fā)能量代謝紊亂，破壞機(jī)體的免疫代謝穩(wěn)態(tài)，導(dǎo)致肥胖、衰老及多種免疫代謝疾病的發(fā)生，如糖尿病、脂肪肝、心血管代謝病、癌癥及感染、炎癥相關(guān)疾病，我國(guó)的人口老齡化則加劇了這些健康問(wèn)題的嚴(yán)峻形勢(shì)。因此，闡明能量的代謝穩(wěn)態(tài)如何響應(yīng)各種應(yīng)激因素的應(yīng)答機(jī)制，對(duì)于研究免疫代謝疾病及健康穩(wěn)態(tài)的調(diào)控機(jī)理，推動(dòng)面向人民生命健康的基礎(chǔ)和應(yīng)用研究具有重要意義。

由于各組織器官具有不同的代謝功能，因此能量代謝的穩(wěn)態(tài)調(diào)控涉及多個(gè)組織器官間的功能互作、代謝模式的時(shí)空協(xié)同和代謝信息的交流對(duì)話。為了研究各組織器官如何協(xié)同響應(yīng)不同能量應(yīng)激的關(guān)鍵科學(xué)問(wèn)題，需要從組織器官間對(duì)話網(wǎng)絡(luò)（inter-organ communication）的維度突破能量感應(yīng)調(diào)控與異常的研究瓶頸。例如，不同營(yíng)養(yǎng)、飲食或生理與病理因素重塑能量代謝的過(guò)程中，骨骼?。芰肯模┡c脂肪（能量?jī)?chǔ)存）、腸及大腦（能量感應(yīng)、消耗及攝取）之間的代謝互作模式和信息對(duì)話機(jī)制仍亟待解決。因此，鑒定不同營(yíng)養(yǎng)、飲食或生理與病理應(yīng)激誘導(dǎo)的代謝酶、代謝物和分泌因子，揭示其介導(dǎo)組織或器官間對(duì)話的信號(hào)通路，闡明能量代謝適應(yīng)性轉(zhuǎn)換的調(diào)控機(jī)制，已成為生命健康研究的關(guān)鍵挑戰(zhàn)。

本課題組聚焦上述面向人民生命健康的關(guān)鍵科學(xué)問(wèn)題，長(zhǎng)期致力于研究器官間對(duì)話調(diào)控免疫代謝穩(wěn)態(tài)的分子機(jī)制，探索各種生理/病理應(yīng)激因素誘發(fā)組織器官間的能量代謝失衡，進(jìn)而導(dǎo)致免疫代謝紊亂并最終影響健康、衰老與壽命的生理機(jī)理。因此，本課題組將系統(tǒng)性闡明器官間能量感應(yīng)體系的適應(yīng)性響應(yīng)機(jī)理，為研究免疫代謝紊亂相關(guān)的疾病和健康穩(wěn)態(tài)提供關(guān)鍵的理論基礎(chǔ)，主要研究方向包括：

（1）不同營(yíng)養(yǎng)、生理與病理應(yīng)激下，能量代謝系統(tǒng)與天然免疫系統(tǒng)之間的協(xié)同整合機(jī)制。

（2）組織及器官間的免疫代謝穩(wěn)態(tài)調(diào)控衰老、肥胖、糖尿病、慢性炎癥等免疫代謝障礙的分子機(jī)制。

（3）組織或器官間對(duì)話調(diào)控免疫代謝穩(wěn)態(tài)的應(yīng)激響應(yīng)機(jī)制及其影響健康穩(wěn)態(tài)的分子機(jī)理。

**代表性研究成果（#第一作者，*通訊作者）：**

1. Xiao Zhao# and Jason Karpac*. Glutamate Metabolism Directs Energetic Trade-offs to Shape Host-Pathogen Susceptibility in Drosophila. Cell Metabolism, 2021, 33: 1-17.

2. Xiao Zhao# and Jason Karpac*. The Drosophila midgut and the systemic coordination of lipid- dependent energy homeostasis. Current Opinion Insect Science, 2020, 41:100-105.

3. Zhao Xiao#, Li X#., Shi X., Karpac J*. (2020). Diet-MEF2 interactions shape lipid droplet diversification in muscle to influence Drosophila lifespan. Aging Cell, 2020, e13172.

4. Xiao Zhao# and Jason Karpac*. Muscle directs diurnal energy homeostasis through a myokine- dependent hormone module in Drosophila. Current Biology, 2017, 27 (13): 1941-1955.e6.

5. Xiao Zhao#, Zhaoyang Liu, Qing-Xin Liu*. Gene coexpression networks reveal key drivers of phenotypic divergence in porcine muscle. BMC genomics, 2015, 16(1):50.

6. Xiao Zhao#, Qi Yu, Ling Huang and Qing-Xin Liu*. Patterns of positive selection of the complete myogenic regulatory factor gene family in vertebrates. PLoS ONE, 2014, 9(3): e92873.

7. Xiao Zhao#, Zheng Huang, Xiaohong Liu, Yaosheng Chen,Wen Gong, Kaifan Yu, Lijun Qin, Hu Chen, Delin Mo*. The switch role of the Tmod4 in the regulation of balanced development between myogenesis and adipogenesis. Gene, 2013, 532 (12): 263-271.

8. Ling Huang#, Xiao Zhao#, Qi Yu, Wei-Zheng Cui and Qing-Xin Liu*. Evidence for the Coevolution of Axon Guidance Molecule Netrin and its Receptor Frazzled. Gene, 2014, 544 (1): 25-31.

9. Xiao Zhao#, Delin Mo, Anning Li, Wen Gong, Shuqi Xiao, Yue Zhang, Limei Qin, Yuna Niu, Yunxue Guo, Xiaohong Liu, Peiqing Cong, Zuyong He, Chong Wang, Jiaqi Li, Yaosheng Chen*. Comparative analyses by deep-sequencing of transcriptome during skeletal muscle development between two swine breeds differing in muscle growth and fatness. PLoS ONE, 2011, 6(5): e19774.

10. Xiao Zhao#, Delin Mo, Anning Li, Wen Gong, Yue Zhang, Weiwei Qian, Weiquan Chen, Shuqi Xiao, Yaosheng Chen*. Characterization and transcriptional regulation analysis of the porcine PAQR6 gene. DNA and CELL BIOLOGY, 2011, 30 (11): 1-8.

11. Chi G. Weindel; Eduardo L. Martinez; Xiao Zhao; Cory J. Mabry; Samantha L. Bell; Krystal J. Vail; Aja K. Coleman; Jordyn J. VanPortfliet; Baoyu Zhao; Allison R. Wagner; Sikandar Azam; Ha ley M. Scott; Pingwei Li; A. Phillip West; Jason Karpac; Kristin L. Patrick; Robert O. Watson; Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis, cell, 2022, 185(17): 1-18

12. Zhao Xiao#, Mo De-Lin, Zhang Yue, Chen Yao-Sheng*. Progress in research on skeletal muscle growth and development in swine. Chinese Bulletin of Life Sciences, 2011, 23 (1): 1-8.

13. MA Karim Rumi, Prabhakar Singh, Katherine F. Roby, Xiao Zhao, Khursheed Iqbal, Anamika Ratri, Tianhua Lei, Wei Cui, Shaon Borosha, Pramod Dhakal, Kaiyu Kubota, Damayanti Chakraborty, Jay L. Vivian, Michael W. Wolfe, Michael J. Soares. Defining the Role of Estrogen Receptor β in the Regulation of Female Fertility. Endocrinology, 2017 en.2016-1916.

14. Qi Yu, Xiao-Tong Li, Xiao Zhao, Xun-Li Liu and Qing-Xin Liu. Coevolution of Axon Guidance Molecule Slit and its Receptor Robo. PLoS ONE, 2014, 10.1371/journal.pone.0094970.

15. Anning Li, Delin Mo, Xiao Zhao, Wei Jiang, Peiqing Cong, Zuyong He, Shuqi Xiao, Xiaohong Liu, Yaosheng Chen. Comparison of the longissimus muscle proteome between obese and lean pigs at 180 days. Mamm Genome, 2013, 24(1-2):72-9.

16. Yu Qi, Zhou QiSheng, Zhao Xiao, Liu QingXin. Current progress in functions of axon guidance molecule Slit and underlying molecular mechanism. Sheng Li Xue Bao, 2012, 64(2):220-30.

17. Anning Li, Yaosheng Chen, Xiao Zhao, Yuna Niu, Peiqing Cong, Zongwu Zhang, Weiquan Chen, Wei Jiang, Delin Mo. Characterization and transcriptional regulation analysis of the porcine TNFAIP8L2 gene. Mol Genet Genomics, 2010.284(3):185-95

18. Xiao-Tong Li, Qi Yu, Qi-Sheng Zhou, Xiao Zhao, Zhao-Yang Liu, Wei-Zheng Cui, Qing-Xin Liu. BmRobo1a and BmRobo1b control axon repulsion in the silkworm Bombyx mori. Gene, 2016, 577(2): 215-220.

19. Xiao-Tong Li, Qi Yu, Qi-Sheng Zhou, Xiao Zhao, ZY Liu, WZ Cui, Qing-Xin Liu. BmRobo2/3 is required for axon guidance in the silkworm Bombyx mori. Gene, 2016, 577(2): 174-179.

20. Qi Yu, Xiao-Tong Li, Chun Liu, Wei-Zheng Cui, Zhi-Mei Mu, Xiao Zhao, Qing-Xin Liu. Evolutionarily Conserved Repulsive Guidance Role of Slit in the Silkworm Bombyx mori. PLoS ONE, 2014, Oct 6;9(10):e109377.

21. Li Xiao-Tong, Zhou Qi-Sheng, Yu Qi, Zhao Xiao, Liu Qing-Xin. Current progress in functions of axon guidance molecule Robo and underlying molecular mechanism. Acta Physiologica Sinica, June 25, 2014, 66(3): 373–385

22. Weiquan Chen, Yaosheng Chen, Limei Qin, Anning Li, Xiao Zhao, Xiaoying Wang, Shuqi Xiao, Delin Mo. Transcription Factor Sp1 is Essential for the Regulation of the Porcine Caveolin-1 Gene. DNA and CELL BIOL, 2011, 30 (7): 491-497.

23. Niu Y, Mo D, Qin L, Wang C, Li A, Zhao X, Wang X, Xiao S, Wang Q, Xie Y, He Z, Cong P, Chen Y. LPS-induced miR-1224 negatively regulates tumor necrosis factor-alpha gene expression by modulating Sp1. Immunology, 2010.10.1111.

24. Zongwu Zhang, Delin Mo, Fei Ling, Chong Wang, Anning Li, Xiao Zhao, Yanfang Li, and Yaosheng Chen. Characterization and promoter activity analysis of a new porcine gene: NICE- 3. DNA Cell Biol, 2010. 29 (3):141-147.

25. Shuqi Xiao, Jianyu Jia, Delin Mo, Qiwei Wang, Limei Qin, Zuyong He, Xiao Zhao, Yuankai Huang, Anning Li, Jingwei Yu, Yuna Niu, Xiaohong Liu, Yaosheng Chen. Understanding PRRSV infection in porcine lung based on genome-wide transcriptome response identified by deep sequencing. PLoS ONE, 2010.5(6):e11377.

26. Shuqi Xiao, Delin M, Qiwei W, Jianyu J, Limei Q, Xiangchun Y, Yuna N, Xiao Zhao, Xiaohong L, Yaosheng Chen. Aberrant immune response in infection of pigs with the highly virulent PRRSV (H-PRRSV) identified by high-throughput Solexa sequencing. BMC Genomics, 2010, 11:544.

27. Zhisheng Zhang, Delin Mo, Peiqing Cong, Zuyong He, Fei Ling, Anning Li, Yuna Niu, Xiao Zhao, Chunyan Zhou, Yaosheng Chen. Molecular cloning, expression patterns and subcellular localization of porcine TMCO1 gene. Mol. Biol. Rep, 2010. 37(3):1611-1618.

28. Limei Qin, Yaosheng Chen, Yuna Niu, Weiquan Chen, Qiwei Wang, Shuqi Xiao, Anning Li, Ying Xie, Jing Li, Xiao Zhao, Zuyong He and Delin Mo. A deep investigation into the adipogenesis mechanism: Profile of microRNAs regulating adipogenesis by modulating the canonical Wnt/beta-catenin signaling pathway. BMC Genomics, 2010.11:320.

論著之外的代表性研究成果和學(xué)術(shù)獎(jiǎng)勵(lì):

1. Xiao Zhao; Jason Karpac ; Muscle directs diurnal energy homeostasis through a myokine-dep endent hormone module in Drosophila, 59th Annual Drosophila Research Conference, Philadelphia, PA , 2018-4-11 至 2018-4-15 (會(huì)議報(bào)告)

2. Xiao Zhao; Jason Karpac ; Muscle directs diurnal energy homeostasis through a myokine-dep endent hormone module in Drosophila, 23rd Annual COM-GSO research symposium, College Station, TX, 2018-4-20 至 2018-4-20 (會(huì)議報(bào)告)

3. 趙曉; 莫德林; 李安寧; 陳衛(wèi)權(quán); 張宗武; 張之晟; 肖書奇; 覃麗梅; 牛玉娜; 陳瑤生 ; 豬 TMOD4 基因的克隆、組織表達(dá)譜、亞細(xì)胞定位以及啟動(dòng)子分析, 第十五次全國(guó)動(dòng)物遺傳育種學(xué)術(shù)討論會(huì), 楊凌，陜西, 2009-10-10 至 2009-10-14 (會(huì)議報(bào)告)

4. Xiao Zhao; Jason Karpac ; Muscle directs diurnal energy homeostasis through a myokine-dep endent hormone module in Drosophila, 44th Annual Meeting of the Texas Genetics Society,

College S tation, TX, 2017-4-27 至 2017-4-29 (會(huì)議報(bào)告)

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