研究方向

林一瀚課題組的研究聚焦在單細胞水平上定量解析人類發(fā)育、疾病及免疫等重要過程中的基因調控機制，并利用合成生物器件對這些過程實施精準干擾或控制。研究從以下幾個方面展開：在單細胞水平上動態(tài)解析腫瘤及免疫細胞的狀態(tài)異質性、表觀機制對基因表達和細胞群體異質性的影響、轉錄因子動力學在信號傳導及基因調控中的功能和設計原理、數據驅動的基因調控網絡推斷及構建，及新型合成生物學器件的設計和應用。

實驗室致力于開展前沿的生命科學交叉研究，有機結合了包括系統(tǒng)生物學、合成生物學、定量單細胞分析、活細胞時序熒光成像、數學建模等研究方法。同時，為了引領單細胞研究領域，實驗室正在研發(fā)高通量、高時空分辨率的單細胞分析工具，用于解析疾病過程中的基因調控網絡，并為單細胞水平上藥物篩選及大規(guī)模測試合成生物學器件等應用提供新平臺。

代表性科研論文

1.      Lingfeng Xue, Yan Wu, Yihan Lin*. Dissecting and improving gene regulatory network inference using single-cell transcriptome data. Genome Research, 2023, doi:10.1101/gr.277488.122.

2.      Jianhan Zhang, Xu Han, Liang Ma, Shuhui Xu, Yihan Lin*. Deciphering a global source of non-genetic heterogeneity in cancer cells. Nucleic Acids Research, 2023, gkad666.

3.      Wen Huang, Wei Lin, Baoqiang Chen, Jianhan Zhang, Peifen Gao, Yingying Fan, Yihan Lin*, Ping Wei*, NFAT and NF-κB dynamically co-regulate TCR and CAR signaling responses in human T cells, Cell Reports, 2023, 42(7):112663.

4.      Jiegen Wu#, Baoqiang Chen#, Yadi Liu, Liang Ma, Wen Huang, Yihan Lin*, Modulating gene regulation function by chemically controlled transcription factor clustering, Nature Communications, 2022, 13:2663.

5.      Yan Wu#, Lingfeng Xue#, Huang Wen#, Minghua Deng, Yihan Lin*, Profiling transcription factor activity dynamics using intronic reads in time-series transcriptome data, PLOS Computational Biology, 2022, 18(1): e1009762.

6.      Liang Ma, Zeyue Gao, Jiegen Wu, Bijunyao Zhong, Yuchen Xie, Wen Huang, Yihan Lin*. Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics. Molecular Cell, 2021, 81:1682-1697.

7.      Yan Wu, Jiaqi Wu, Minghua Deng, Yihan Lin*. Yeast cell fate control by temporal redundancy modulation of transcription factor paralogs. Nature Communications, 2021, 12(1):3145.

8.      Jiegen Wu, Xu Han, Haotian Zhai, Tingyu Yang, Yihan Lin*, Evidence for rate-dependent filtering of global extrinsic noise by biochemical reactions in mammalian cells, Molecular Systems Biology, 2020, 16: e9335.

9.      Jianhan Zhang#, Xu Han#, Yihan Lin*, Dissecting the regulation and function of ATP at the single-cell level, PLOS Biology, 2018, 16(12): e3000095 (Primer).

10.   Bingteng Xie, Yang Pu, Fan Yang, Wei Chen, Wei Yue, Jihong Ma, Na Zhang, Yuening Jiang, Jiegen Wu, Yihan Lin, Xin Liang, Chu Wang, Peng Zou*, Mo Li*, Proteomic mapping and targeting of mitotic pericentriolar material in tumors bearing centrosome amplification, Cancer Research, 2022, 82 (14): 2576–2592.

11.   Rosa Martinez-Corral, Elba Raimundez, Yihan Lin, Michael B Elowitz, Jordi Garcia-Ojalvo*, Self-amplifying pulsatile protein dynamics without positive feedback, Cell Systems, 2018, 7(4): 453-462.

12.   Jin Park, Marta Dies, Yihan Lin, Sahand Hormoz, Stephanie E. Smith-Unna, Sofia Quinodoz, María Jesús Hernández-Jiménez, Jordi Garcia-Ojalvo#, James C.W. Locke#, Michael B. Elowitz#, Molecular time sharing through dynamic pulsing in single cells, Cell Systems, 2018, 6(2): 216-229.

13.   Yuval Yifat, Nishant Sule, Yihan Lin, Norbert F. Scherer, Analysis and correction of errors in nanoscale particle tracking using the Single-pixel interior filling function (SPIFF) algorithm, Scientific Reports, 2017, 7, 16553.

# equal contributions

* corresponding author

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