目的

探討正常人直腸電刺激腦誘發(fā)電位（CEP）的正常值及波形特征。

方法

檢查者將刺激電極經(jīng)肛置入受試者直腸內(nèi)，在頭頂部Cz點(diǎn)放置記錄電極，參考電極置于前額部Fz點(diǎn)，使用英國(guó)Oxford公司肌電誘發(fā)電位儀采樣分析。

結(jié)果

所有檢測(cè)對(duì)象均記錄有直腸電刺激腦誘發(fā)電位，各波參數(shù)范圍分別是：P1波潛伏期（45.55±3.26）ms，N1波（101.71±15.71）ms，P2波（198.35±27.70）ms，P1/N1波幅（5.62±1.58）μV，N1/P2波幅（8.26±2.48）μV。直腸電刺激腦誘發(fā)電位各波潛伏期及波幅在性別、年齡分組間比較，差異無(wú)統(tǒng)計(jì)學(xué)意義。經(jīng)一般線性回歸分析發(fā)現(xiàn)，在控制年齡分組、性別后，波幅隨BMI增加而降低，BMI每增加1 kg/m2，P1/N1波幅平均下降0.234 μV（P=0.011），N1/P2波幅平均下降0.320 μV（P=0.027）。

結(jié)論

直腸電刺激腦誘發(fā)電位提供了一種簡(jiǎn)單、有效的評(píng)估直腸到大腦皮層感覺(jué)神經(jīng)通路的方法。本研究對(duì)了解功能性胃腸疾病中的腦腸互動(dòng)作用具有重要價(jià)值。本研究的檢測(cè)結(jié)果及其影響因素分析，可供后續(xù)臨床研究借鑒。

Objective

To investigate the normal range and waveform characteristics of rectal electrical stimulation cerebral evoked potential (CEP) in healthy people.

Methods

The examiner placed the stimulus electrode in the rectum of the subjects through the anus, the recording electrode at Cz point on the top of the head, the reference electrode at Fz point on the forehead and sampled by Oxford EMP.

Results

Rectal electrical stimulation cerebral evoked potentials were recorded in all subjects. The waveform parameters are P1 wave latency (45.55±3.26) ms, N1 wave (101.71±15.71) ms, P2 wave (198.35±27.70) ms, P1/N1 amplitude (5.62±1.58) μV, N1/P2 amplitude (8.26±2.48) μV. There was no significant difference in latency and amplitude of the evoked potential waves between sex and age groups. By general linear regression analysis, it was found that the amplitude decreased with the increase of BMI after controlling age group and sex. For each increase of BMI of 1 kg/m2, the amplitude of P1/N1 decreased by 0.234 μV (P=0.011), and the amplitude of N1/P2 decreased by 0.320 μV (P=0.027).

Conclusion

Rectal electrical stimulation cerebral evoked potentials provides a simple and effective method for evaluating the sensory nerve pathway from rectum to cerebral. This study is of great value in understanding the brain-intestinal interaction in functional gastrointestinal diseases. The results of this study and the analysis of its influencing factors can be used for reference in the follow-up clinical research.

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