首頁 資訊 茶葉減肥降脂機制研究進展

茶葉減肥降脂機制研究進展

來源:泰然健康網(wǎng) 時間:2024年12月06日 08:27

摘要: 肥胖是由于食欲調(diào)節(jié)和能量代謝功能長期紊亂引起的體內(nèi)脂肪積累。肥胖與多種疾病密切相關,因此尋求高效、安全的減肥藥物成為人們的共同愿望。茶葉因其良好的降脂減肥效果,日益引起國內(nèi)外眾多學者的關注。近年來,茶葉減肥機理成為研究的熱點,并取得了顯著成效。本文綜述了最近幾年對茶葉減肥作用的機理研究,即茶葉及其組分抑制營養(yǎng)吸收、改善脂質(zhì)代謝、促進脂肪細胞凋亡和調(diào)節(jié)肥胖相關基因等方面的研究進展。 

關鍵詞: 肥胖;  /  茶葉;  /  減肥機理;  

Abstract: Obesity may occur after long period of disoders in appetite and energy metabolism regulations.Obesity is strongly associated with many diseases.Therefore, searching for the high effective and safe anti-obesity medicine has become the common aspiration of people.Tea, with its putative function of anti-obesity, has attracted more and more attention all over the world.In recent years, tens of literatures were focused on the mechanism of the anti-obesity effects of tea.In this paper, recent progress on tea anti-obesity mechanism was reviewed, including inhibiting the absorption of nutritients, improving lipid metabolism, promoting lipoapoptosis, regulation of obesity-related genes, and a plausible pathway.

[1]

PARK K W, LEE J E, PARK K M.Diets containing Sophora japonica L.prevent weight gain in high-fat diet-induced obese mice[J].Nutr Res, 2009, 29 (11) :819-824.

[2]

GUO Y, WU G, SU X, et al.Antiobesity action of a daidzein derivative on male obese mice induced by a high-fat diet[J].Nutr Res, 2009, 29 (9) :656-663.

[3]

EJAZ A, WU D, KWAN P, et al.Curcumin inhibits adipogenesis in3T3-L1adipocytes and angiogenesis and obesity in C57/BL mice[J].The Journal of nutrition, 2009, 139 (5) :919-925.

[4] 陸志強.減肥藥的不良反應及正確使用[J].中國處方藥, 2003, 9:88-91. [5]

HUANG H C, LIN J K.Pu-erh tea, green tea, and black tea suppresses hyperlipidemia, hyperleptinemia and fatty acid synthase through activating AMPK in rats fed a high-fructose diet[J].Food&function, 2012, 3 (2) :170-177.

[6]

CROZIER A, JAGANATH I B, CLIFFORD M N.Dietary phenolics:chemistry, bioavailability and effects on health[J].Natural Product Reports, 2009, 26 (8) :1001-1043.

[7]

ZHAO Y, CHEN P, LIN L, et al.Tentative identification, quantitation, and principal component analysis of green pu-erh, green, and white teas using UPLC/DAD/MS[J].Food Chemistry, 2011, 126 (3) :1269-1277.

[8]

LIN J K, LIN-SHIAU S Y.Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols[J].Molecular Nutrition&Food Research, 2006, 50 (2) :211-217.

[9]

OI Y, HOU I C, FUJITA H, et al.Antiobesity effects of Chinese black tea (Pu-erh tea) extract and gallic acid[J].Phytotherapy research:PTR, 2012, 26 (4) :475-481.

[10]

UCHIYAMA S, TANIGUCHI Y, SAKA A, et al.Prevention of diet-induced obesity by dietary black tea polyphenols extract in vitro and in vivo[J].Nutrition, 2011, 27 (3) :287-292.

[11]

GONDOIN A, GRUSSU D, STEWART D, et al.White and green tea polyphenols inhibit pancreatic lipase in vitro[J].Food Research International, 2010, 43 (5) :1537-1544.

[12]

SHISHIKURA Y, KHOKHAR S, MURRAY B S.Effects of tea polyphenols on emulsification of olive oil in a small intestine model system[J].Journal of Agricultural and Food Chemistry, 2006, 54 (5) :1906-1913.

[13]

IKEDA I, TSUDA K, SUZUKI Y, et al.Tea catechins with a galloyl moiety suppress postprandial hypertriacylglycerolemia by delaying lymphatic transport of dietary fat in rats[J].The Journal of Nutrition, 2005, 135 (2) :155-159.

[14] 范志飛, 曾維才, 戴吉領, 等.表沒食子兒茶素沒食子酸酯與豬胰脂肪酶的相互作用[J].食品科學, 2012, 34 (7) :20-23. [15]

BOSE M, LAMBERT J D, JU J, et al.The major green tea polyphenol, (-) -epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice[J].The Journal of Nutrition, 2008, 138 (9) :1677-1683.

[16]

JOHNSTON K, SHARP P, CLIFFORD M, et al.Dietary polyphenols decrease glucose uptake by human intestinal Caco-2cells[J].FEBS Letters, 2005, 579 (7) :1653-1657.

[17]

ZHONG L, FURNE J K, LEVITT M D.An extract of black, green, and mulberry teas causes malabsorption of carbohydrate but not of triacylglycerol in healthy volunteers[J].The American Journal of Clinical Nutrition, 2006, 84 (3) :551-555.

[18]

VENABLES M C, HULSTON C J, COX H R, et al.Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans[J].The American Journal of Clinical Nutrition, 2008, 87 (3) :778-784.

[19]

PARK J H, JIN J Y, BAEK W K, et al.Ambivalent role of gallated catechins in glucose tolerance in humans:a novel insight into non-absorbable gallated catechin-derived inhibitors of glucose absorption[J].Journal of Physiology and Pharmacology:an Official Journal of the Polish Physiological Society, 2009, 60 (4) :101-109.

[20]

BAHORUN T, LUXIMON-RAMMA A, NEERGHEEN-BHUJUN V S, et al.The effect of black tea on risk factors of cardiovascular disease in a normal population[J].Preventive Medicine, 2012, 54:98-102.

[21]

HOU Y, SHAO W, XIAO R, et al.Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model[J].Experimental Gerontology, 2009, 44 (6-7) :434-439.

[22]

GOTO T, SAITO Y, MORIKAWA K, et al.Epigallocatechin gallate changes mRNA expression level of genes involved in cholesterol metabolism in hepatocytes[J].The British Journal of Nutrition, 2012, 107 (6) :769-773.

[23]

PEREZ-JIMENEZ A, PERES H, RUBIO V C, et al.Effects of diet supplementation with white tea and methionine on lipid metabolism of gilthead sea bream juveniles (Sparus aurata) [J].Fish Physiology and Biochemistry, 2012, 39 (3) :661-670.

[24]

IKEDA I, HAMAMOTO R, UZU K, et al.Dietary gallate esters of tea catechins reduce deposition of visceral fat, hepatic triacylglycerol, and activities of hepatic enzymes related to fatty acid synthesis in rats[J].Bioscience, Biotechnology, and Biochemistry, 2005, 69 (5) :1049-1053.

[25] 袁華兵, 鐘婕, 易娟, 等.普洱茶提取物對飲食誘導肥胖大鼠脂質(zhì)合成相關基因表達的影響[J].營養(yǎng)學報, 2009, 31 (2) :167-171. [26]

CHIANG C T, WENG M S, LIN-SHIAU S Y, et al.Pu-erh tea supplementation suppresses fatty acid synthase expression in the rat liver through downregulating Akt and JNK signalings as demonstrated in human hepatoma HepG2cells[J].Oncology Research, 2005, 16 (3) :119-128.

[27]

WAY T D, LIN H Y, KUO D H, et al.Pu-erh tea attenuates hyperlipogenesis and induces hepatoma cells growth arrest through activating AMP-activated protein kinase (AMPK) in human HepG2cells[J].Journal of Agricultural and Food Chemistry, 2009, 57 (12) :5257-5264.

[28]

KAO C C, WU B T, TSUEI Y W, et al.Green tea catechins:inhibitors of glycerol-3-phosphate dehydrogenase[J].Planta Medica, 2010, 76 (7) :694-696.

[29]

LEE M S, KIM C T, KIM I H, et al.Inhibitory effects of green tea catechin on the lipid accumulation in3T3-L1adipocytes[J].Phytotherapy Research:PTR, 2009, 23 (8) :1088-1091.

[30]

LEE M S, KIM C T, KIM Y.Green tea (-) -epigallocatechin-3-gallate reduces body weight with regulation of multiple genes expression in adipose tissue of diet-induced obese mice[J].Annals of Nutrition&Metabolism, 2009, 54 (2) :151-157.

[31]

GONG J, PENG C, CHEN T, et al.Effects of theabrownin from pu-erh tea on the metabolism of serum lipids in rats:mechanism of action[J].Journal of Food Science, 2010, 75 (6) :H182-189.

[32]

NOMURA S, ICHINOSE T, JINDE M, et al.Tea catechins enhance the mRNA expression of uncoupling protein1in rat brown adipose tissue[J].The Journal of Nutritional Biochemistry, 2008, 19 (12) :840-847.

[33]

TOKIMITSU I.Effects of tea catechins on lipid metabolism and body fat accumulation[J].Biofactors, 2004, 22 (1-4) :141-143.

[34]

MURASE T, NAGASAWA A, SUZUKI J, et al.Beneficial effects of tea catechins on diet-induced obesity:stimulation of lipid catabolism in the liver[J].International Journal of Obesity and Related Metabolic Disorders:Journal of the International Association for the Study of Obesity, 2002, 26 (11) :1459-1464.

[35]

PARK H J, DINATALE D A, CHUNG M Y, et al.Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice[J].The Journal of Nutritional Biochemistry, 2011, 22 (4) :393-400.

[36]

CAO Z H, YANG H, HE Z L, et al.Effects of Aqueous Extracts of Raw Pu-erh Tea and Ripened Pu-Erh Tea on Proliferation and Differentiation of3T3-L1Preadipocytes[J].Phytotherapy Research:PTR, 2012, Online First.

[37]

KU H-C, LIU H-S, HUNG P-F, et al.Green tea (-) -epigallocatechin gallate inhibits IGF-I and IGF-IIstimulation of3T3-L1preadipocyte mitogenesis via the67-kDa lamininreceptor, but not AMP-activated protein kinase pathway[J].Molecular Nutrition&Food Research, 2012, 56 (4) :580-592.

[38]

CHAN C Y, WEI L, CASTRO-MU OZLEDO F, et al. (-) -Epigallocatechin-3-gallate blocks3T3-L1adipose conversion by inhibition of cell proliferation and suppression of adipose phenotype expression[J].Life Sciences, 2011, 89 (21-22) :779-785.

[39]

LIN J, DELLA-FERA M A, BAILE C A.Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in3T3-L1adipocytes[J].Obesity Research, 2005, 13 (6) :982-990.

[40] 孫世利, 凌彩金, 劉軍, 等.茶多酚與茶黃素對前脂肪細胞3T3-L1增殖與分化的影響[J].廣東農(nóng)業(yè)科學, 2011, 38 (12) :137-139. [41]

WU B T, HUNG P F, CHEN H C, et al.The apoptotic effect of green tea (-) -epigallocatechin gallate on3T3-L1preadipocytes depends on the Cdk2pathway[J].Journal of Agricultural and Food Chemistry, 2005, 53 (14) :5695-5701.

[42]

LU C, ZHU W, SHEN C L, et al.Green tea polyphenols reduce body weight in rats by modulating obesity-related genes[J].PloS One, 2012, 7 (6) :e38332.

[43]

YANG D J, HWANG L S.Study on the conversion of three natural statins from lactone forms to their corresponding hydroxy acid forms and their determination in Pu-Erh tea[J].Journal of Chromatography A, 2006, 1119 (1-2) :277-284.

相關知識

普洱茶減肥降脂機制明確
茶葉健康與茶制品產(chǎn)業(yè)創(chuàng)新發(fā)展大會成功舉辦
減肥降脂喝什么茶比較好?推薦幾種有效的茶葉,有助于減肥和降低血脂。
普洱茶有助降脂減肥
怎樣喝荷葉茶減肥?4款自制荷葉茶讓你快速消脂
喝茶葉能減肥嗎
研究進展
肥宅福音!綠茶+柑橘多酚=減肥降脂新搭檔!
微塑料的人體富集及毒性機制研究進展
減肥茶=茶葉+瀉藥?!

網(wǎng)址: 茶葉減肥降脂機制研究進展 http://m.u1s5d6.cn/newsview308675.html

推薦資訊