摘要

添加輔食對促進(jìn)嬰兒健康和發(fā)育至關(guān)重要。在斷奶期間，膳食模式可提供必需的營養(yǎng)素，并促進(jìn)多樣化腸道微生物群的發(fā)展，而腸道微生物群在調(diào)節(jié)免疫、代謝和神經(jīng)功能方面發(fā)揮著重要作用。這項(xiàng)研究招募了 200 個(gè)家庭，以評估輔食對嬰兒生長和健康結(jié)果的影響。數(shù)據(jù)包括喂養(yǎng)方式的詳細(xì)記錄、嬰兒生長測量、健康評估以及產(chǎn)后第 12 周至第 32 周收集的糞便樣本和母乳。利用 16S rRNA 測序分析了腸道微生物組，并利用色譜-質(zhì)譜法測量了母乳低聚糖（HMO）、單糖和短鏈脂肪酸（SCFA）等代謝物。結(jié)果顯示，母乳喂養(yǎng)的比例很高，16 周左右開始添加輔食。嬰兒腸道微生物群發(fā)生了顯著變化，尤其是乳酸桿菌屬、阿克曼菌屬和葡萄球菌屬。此外，還發(fā)現(xiàn) HMOs、單糖和 SCFAs 的含量受添加輔食的影響。輔食喂養(yǎng)方式、腸道微生物組多樣性、特定細(xì)菌屬（如鏈球菌、乳酸桿菌、雙歧桿菌和梭狀芽孢桿菌）和關(guān)鍵代謝物（如乳-N-四糖、乳-N-新四糖、甘露糖和丁酸）之間存在顯著的相關(guān)性。這項(xiàng)研究為了解嬰兒早期生長過程中輔食喂養(yǎng)、腸道微生物組發(fā)育和代謝物之間復(fù)雜的相互作用提供了寶貴的見解。建議今后開展更大規(guī)模的隊(duì)列研究和有針對性的飲食干預(yù)，以進(jìn)一步闡明其潛在機(jī)制。

本文章由計(jì)算機(jī)程序翻譯，如有差異，請以英文原文為準(zhǔn)。

Impact of complementary feeding on infant gut microbiome, metabolites and early development?

Introducing complementary foods is critical for promoting infant health and development. During the weaning period, the dietary patterns provide essential nutrients and facilitate the development of a diverse gut microbiome, which plays significant roles in the regulation of immune, metabolic, and neurological functions. This study enrolled 200 families to assess the impact of complementary feeding on infant growth and health outcomes. Data included detailed records of feeding practices, infant growth measurements, health assessments, and fecal samples and breast milk collected between weeks 12 and 32 postpartum. The gut microbiome was analyzed using 16S rRNA sequencing, while metabolites such as human milk oligosaccharides (HMOs), monosaccharides, and short-chain fatty acids (SCFAs) were measured using chromatography-mass spectrometry. Results revealed a high prevalence of breastfeeding, with complementary food introduced at around 16 weeks. Significant alterations in the infant gut microbiome were observed, particularly in the genera Lactobacillus, Akkermansia, and Staphylococcus. Additionally, the levels of HMOs, monosaccharides, and SCFAs were found to be influenced by the introduction of complementary foods. Significant correlations emerged between complementary feeding practices, gut microbiome diversity, specific bacterial genera (e.g., Streptococcus, Lactobacillus, Bifidobacterium, and Clostridioides), and key metabolites (such as lacto-N-tetraose, lacto-N-neotetraose, mannose, and butyric acid). This study offers valuable insights into the complex interactions between complementary feeding, gut microbiome development, and metabolite profiles during early infant growth. Future research with larger cohorts and targeted dietary interventions is recommended to further elucidate the underlying mechanisms.

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網(wǎng)址: 輔食對嬰兒腸道微生物組、代謝物和早期發(fā)育的影響。 http://m.u1s5d6.cn/newsview1377567.html