劉曉娟
科研項目
近年來,主持2項國家自然科學基金項目、1項教育部博士點基金項目、5項廣東省自然科學基金項目、1項廣東省科技計劃項目、1項廣州市重點研發(fā)項目、1項廣州市科技計劃項目、1項廣東省教育廳項目、4項企業(yè)橫向課題等16項,主要參與國家級、省市級各類項目30多項。
主持項目:
1.B類清道夫受體CD36介導的膳食蝦青素異構(gòu)體跨膜轉(zhuǎn)運分子機制,國家自然科學基金,2022.1-2025.12
2.利用秀麗線蟲模型研究左旋和右旋蝦青素的抗氧化活性差異及其分子作用機制,國家自然科學青年基金,2015.1-2017.12
3.基于體外消化/Caco-2細胞模型的食品納米乳液對類胡蘿卜素生物利用率及其機制研究,廣東省自然科學基金項目,2017.5-2020.5
4.基于秀麗線蟲多信號通路調(diào)控的蝦青素延緩衰老分子機制,廣東省自然科學基金項目,2019.10-2022.9
5.食品級賦形劑納米乳液對黃酮類物質(zhì)生物利用率的調(diào)控機制,廣東省自然科學基金項目,2021.1-2023.12
6.天然蝦青素在水產(chǎn)動物飼料中的關(guān)鍵應(yīng)用技術(shù)與產(chǎn)業(yè)化示范,廣州市重點研發(fā)計劃項目,2023.4-2026.3
7.湯臣倍健營養(yǎng)科學研究基金:利用秀麗線蟲和D-半乳糖致衰老小鼠模型研究蝦青素的抗衰老功效及其機制,2019.4-2021.3
8.山莓葉中抗腹瀉活性物質(zhì)的分離鑒定及其作用機理研究,2011年高等學校博士學科點專項科研基金聯(lián)合資助課題,2012.1-2014.12
9.利用山莓葉開發(fā)新型高效安全的抗菌飼料添加劑研究,廣東省科技計劃農(nóng)業(yè)公關(guān)項目,2012.1-2014.12
10.山莓葉中抗腹瀉活性物質(zhì)的分離鑒定及其作用機理研究,廣東省自然科學基金博士啟動項目,2011.10-2013.10
11.山莓葉中抗腹瀉活性物質(zhì)的分離鑒定及其作用機理研究,廣東高校優(yōu)秀青年創(chuàng)新人才培養(yǎng)計劃項目(育苗工程),2012.1-2013.12
12.左旋和右旋蝦青素的抗氧化、延緩衰老活性差異及Insulin/IGF-1通路分子作用機制研究,廣州市科技計劃項目,2017.5-2020.4
13.基于體外消化/Caco-2細胞模型的食品納米乳液對類胡蘿卜素生物利用率及其機制研究,廣東省自然科學基金,2017.5-2020.5
14.梅州市有機稻精深加工技術(shù)研究項目合作,2013.12-2014.6
15.五谷雜糧類食品技術(shù)研究與產(chǎn)品開發(fā),2014.9-2016.8
16.酒粕中高價值活性成分的綠色提取及產(chǎn)品開發(fā),2023.4-2025.3
主要參與項目:
1.基于水分遷移的中超高壓耦合熱處理改善魚糜凝膠特性分子機制研究,國家自然科學基金項目,2020.1-2023.12,排名第3
2.桉葉多酚PGG與OEB抗氧化、延緩衰老的活性差異及分子機制,國家自然科學青年基金項目,2018.1-2020.12,排名第3
3.基于酪蛋白磷酸肽/殼聚糖自組裝構(gòu)建月見草素納米粒及其吸收機制研究,國家自然科學青年基金項目,2014.1-2016.12,排名第5
4.瑞士乳桿菌FX-6發(fā)酵乳中抗菌肽鑒定及其作用機理研究,國家自然科學基金項目,2012.1-2015.12,排名第6
5.超高壓誘導淡水魚糜凝膠及其形成機理研究,國家自然科學基金青年科學基金項目,2012.1-2014.12,排名第5
6.桉葉多酚抗氧化成分提取分離及其抗氧化作用機理研究,國家自然科學基金青年科學基金項目,2012.1-2014.12,排名第5
7.番石榴葉降糖活性物質(zhì)分離純化、結(jié)構(gòu)鑒定與作用機理研究,國家自然科學基金青年科學基金項目,2013.1-2015.12,排名第6
8.潮州市特色佛手產(chǎn)業(yè)升級關(guān)鍵技術(shù)研究與示范,廣東省重大人才工程—“揚帆計劃”引進創(chuàng)新創(chuàng)業(yè)團隊項目,2017.8-2022.12
9.桉葉多酚通過調(diào)控腸道菌群介導的PPAR-α信號通路改善高脂飲食誘導的肥胖,廣東省科學基金,2022.1-2024.12,排名第3
10.南方特色果蔬脂溶性功能成分的安全高效萃取與微膠囊化技術(shù)研究,省國際合作項目,2012.1-2015.12,排名第7
11.低溫連續(xù)相變萃取海洋低值魚魚油的關(guān)鍵技術(shù)及萃取殘渣的綜合利用研究,廣東省公益研究與能力建設(shè),2015.10-2018.9,排名第3
12.桉葉多酚月見草素B的抗氧化、抗衰老作用及其分子機制,廣東省自然科學基金,2015.8-2018.8,排名第4
13.中草藥發(fā)酵化妝品的開發(fā)及功效評價,2013.11-2016.2,排名第2
14.基于微生物-腸道-腦軸探究羊乳源活性肽改善睡眠的作用機制,廣東省自然科學基金,2023.1-2025.12,排名第2
15.基于cAMP/GCG/GLP-1信號通路介導的廣佛手多糖降血糖機制研究,廣東省自然科學基金,2023.1-2025.12,排名第2
學術(shù)論文
以第一作者和通訊作者發(fā)表論文60余篇,其中SCI&EI收錄40多篇(中科院一區(qū)Top期刊17篇,影響因子超100),封面文章6篇。
以第一作者和通訊作者發(fā)表論文:
1. Junlin Zhang, Zhiqing Chen, Yulu Lao, Xuan Pan, Xuan Zhang, Jie Xiao, Liping He, Yong Cao, Xiaojuan Liu*. Cluster of differentiation 36 (CD36) preferentially mediates intestinal absorption of dietary Z-astaxanthin and especially 9-Z-isomer via higher binding affinity. Journal of Agricultural and Food Chemistry, 2024, 72(29): 16287-16297【封面文章,中科院1區(qū),Top期刊,IF5.7
2. Xiaojuan Liu*, Junting Xie, Lesong Zhou, Junlin Zhang, Zhiqing Chen, Jie Xiao, Yong Cao, Hang Xiao*. Recent advances in health benefits and bioavailability of dietary astaxanthin and its isomers. Food Chemistry, 2023, 404: 134605【中科院1區(qū),Top期刊,IF8.8】
3. Xiaojuan Liu*, Yanping Lin, Kangfei Yao, Junting Xie, Jie Xiao, Yong Cao. Increasing ?-carotene bioavailability and bioactivity in spinach demonstrated using excipient nanoemulsions—especially those of long-chain triglycerides. Food Chemistry, 2023, 404: 134194【中科院1區(qū),Top期刊,IF8.8】
4. Xiaojuan Liu*, Junlin Zhang, Zhiqing Chen, Jie Xiao, Aimei Zhou, Yongshui Fu, Yong Cao. Cluster-determinant 36 (CD36) mediates intestinal absorption of dietary astaxanthin and affects its secretion. Food Research International, 2023, 173: 113328【中科院1區(qū),Top期刊,IF8.8】
5. Xiaojuan Liu*, Lesong Zhou, Junting Xie, Junlin Zhang, Zhiqing Chen, Jie Xiao, Yong Cao, Hang Xiao*. Astaxanthin Isomers: A Comprehensive Review of Isomerization Methods and Analytic Techniques. Journal of Agricultural and Food Chemistry, 2023, 71: 19920?19934【封面文章,中科院1區(qū),Top期刊,IF6.1】
6. Junting Xie, Xiaoning Hou, Wanshi He, Jie Xiao, Yong Cao, Xiaojuan Liu*. Astaxanthin reduces fat storage in fat-6/fat-7 dependent manner determined by high fat Caenorhabditis elegans. Food & Function, 2023, 14: 7347-7360【封面文章,中科院1區(qū),Top期刊,IF6.1】
7. Wanshi He, Junting Xie, Zenghui Xia, oyan Chen, Jie Xiao, Yong Cao, Xiaojuan Liu*. The novel peptide derived from Haematococcus pluvialis residues exhibited anti-aging activity in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway. Food & Function, 2023,14, 5576-5588【封面文章,中科院1區(qū),Top期刊,IF6.1】
8. Yanping Lin, David Julian McClements, Jie Xiao, Yong Cao, and Xiaojuan Liu*. In Vitro?In Vivo Study of the Impact of Excipient Emulsions on the Bioavailability and Antioxidant Activity of Flavonoids: Influence of the Carrier Oil Type. Journal of Agricultural and Food Chemistry, 2023, 71: 1488-1498【封面文章,中科院1區(qū),Top期刊,IF6.1】
9. Qinsheng Zheng, Junting Xie, Xiao Jie, Yong Cao, Xiaojuan Liu*. Unraveling the underlying mechanism of interactions between astaxanthin geometrical isomers and bovine serum albumin. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2024, 308: 123731【中科院2區(qū),IF4.3】
10. Xiaojuan Liu*, Han Liu, Zhiqing Chen, Jie Xiao, Yong Cao. DAF-16 acts as the hub of astaxanthin's anti-aging mechanism to improve aging-related physiological functions in Caenorhabditis elegans. Food & Function, 2021, 12: 9098 - 9110【中科院1區(qū),Top期刊,IF6.1】
11. Kangfei Yao, David Julian McClements, Chang Yan, Jie Xiao, Han Liu, Zhiqing Chen, Xiaoning Hou, Yong Cao, Hang Xiao*, Xiaojuan Liu*. In vitro and in vivo study of the enhancement of carotenoid bioavailability in vegetables using excipient nanoemulsions: Impact of lipid content. Food Research International, 2021, 141: 110162【中科院1區(qū),Top期刊,IF8.1】
12. Zhiqing Chen, Jie Xiao, Han Liu, Kangfei Yao, Xiaoning Hou, Yong Cao, Xiaojuan Liu*. Astaxanthin attenuates oxidative stress and immune impairment in D-galactose-induced aging rats by activating Nrf2/Keap1 pathway and suppressing NF-κB pathway. Food & Function, 2020, 11: 8099 – 8111【中科院1區(qū),Top期刊,IF6.1】
13. Han Liu, Xuguang Zhang, Jie Xiao, Mingyue Song, Yong Cao, Hang Xiao*, Xiaojuan Liu*. Astaxanthin attenuates D-galactose-induced brain aging in rats by ameliorating oxidative stress, mitochondrial dysfunction, and regulating metabolic markers. Food & Function, 2020, 11: 4103 - 4113【中科院1區(qū),Top期刊,IF6.1】
14. Kangfei Yao, David Julian McClements, Jiaxin Xiang, Ziying Zhang, Yong Cao, Hang Xiao*, Xiaojuan Liu*. Improvement of carotenoid bioaccessibility from spinach by co-ingesting with excipient nanoemulsions: Impact of oil phase composition. Food & Function, 2019, 10(9): 5302-5311【封面文章,中科院1區(qū),Top期刊,IF6.1】
15. Xi Yuan, Jie Xiao, Xiaojuan Liu*, David Julian McClements, Yong Cao, Hang Xiao*. The gastrointestinal behavior of emulsifiers used to formulate excipient emulsions impact the bioavailability of β-carotene from spinach. Food Chemistry, 2019, 278: 811–819【中科院1區(qū),Top期刊,IF8.8】
16. Xi Yuan, Xiaojuan Liu*, David Julian McClements, Yong Cao, Hang Xiao*. Enhancement of phytochemical bioaccessibility from plant-based foods using excipient emulsions: impact of lipid type on carotenoid solubilization from spinach. Food & Function, 2018, 9(8): 4352- 4365【中科院1區(qū),Top期刊,IF6.1】
17. Xiaojuan Liu*, Ruojie Zhang, David Julian McClements, Fang Li, Han Liu, Yong Cao, Hang Xiao*. Nanoemulsion-based delivery systems for nutraceuticals: Influence of long-chain triglyceride (LCT) type on in vitro digestion and astaxanthin bioaccessibility. Food Biophysics, 2018, 13(4): 412-421【SCI收錄】
18. Xiaojuan Liu*, Xiaofeng Chen, Han Liu, Yong Cao. Antioxidation and anti-aging activities of astaxanthin geometrical isomers and molecular mechanism involved in Caenorhabditis elegans. Journal of Functional Foods, 2018, 44: 127-136【中科院2區(qū),IF3.47】
19. Xiaojuan Liu*, Miao Zhang, Han Liu, Aimei Zhou, Yong Cao, Xin Liu. Preliminary characterization of the structure and immunostimulatory and anti-aging properties of the polysaccharide fraction of Haematococcus pluvialis. RSC Advances, 2018, 8: 9243 – 9252【SCI收錄】
20. Xiaojuan Liu*, Mingyue Song, Zili Gao, Xiaokun Cai, William Dixon, Xiaofeng Chen, Yong Cao, Hang Xiao*. Stereoisomers of astaxanthin inhibit human colon cancer cell growth by inducing G2/M cell cycle arrest and apoptosis. Journal of Agricultural and Food Chemistry, 2016, 64 (41): 7750–7759【中科院1區(qū),Top期刊,IF6.1】
21. Xiaojuan Liu*, Qingxin Luo, Kanyasiri Rakariyatham, Yong Cao, Timothy Goulette, Xin Liu, Hang Xiao*. Antioxidation and anti-ageing activities of different stereoisomeric astaxanthin in vitro and in vivo. Journal of Functional Foods, 2016, 25: 50–61【中科院1區(qū),Top期刊,IF3.973】
22. Xiaojuan Liu, Yicheng Huang, Yunjiao Chen, Yong Cao*. Partial structural characterization, as well as immunomodulatory and anti-aging activities of CP2-c2-s2 polysaccharide from Cordyceps militaris. RSC Advances, 2016, (6): 104094-104103【SCI收錄】
23. Xiaojuan Liu*, Qingxin Luo, Yong Cao, Timothy Goulette, Xin Liu, Hang Xiao*. Mechanism of different stereoisomeric astaxanthin in resistance to oxidative stress in Caenorhabditis elegans. Journal of Food Science,2016, 81(9): 2280-2287【SCI收錄】
24. Xiaojuan Liu*, David Julian McClements, Yong Cao, Hang Xiao*. Chemical and physical stability of astaxanthin-enriched emulsion-based delivery systems. Food Biophysics, 2016, 11(3): 302–310【SCI收錄】
25. Xiaojuan Liu, Qingxin Luo, Yong Cao, Xin Liu, Hang Xiao. Antioxidative activity of (3R,3R’) and (3S,3S’) astaxanthin in Caenorhabditis elegans. The FASEB Journal, 2016, 30(No. 1 Supplement): 689.1【SCI收錄】
26. Xiaojuan Liu, Jiquan Du, Yangwen Ou, Hong Xu, Xuexiang Chen, Aimei Zhou, Liping He, Yong Cao*. Degradation pathway of carnosic acid in methanol solution through isolation and structural identification of its degradation products. European Food Research and Technology, 2013,237(4): 617-626【SCI收錄】
27. Xiaojuan Liu*, Yinghua Wu, Lichao Zhao, Suyao Xiao, Aimei Zhou, Xin Liu. Determination of astaxanthin in Haematococcus pluvialis by first-order derivative spectrophotometry. Journal of AOAC International, 2011, 94(6): 1752-1757【SCI收錄】
28. Xiaojuan Liu, Shun Shan Duan, Ai Fen Li, Ning Xu,Zhuoping Cai,Zhangxi Hu. Effects of organic carbon sources on growth, respiration, and photosynthesis of Phaeodactylum tricornum (Bacillariophyta). Journal of Applied Phycology, 2009, 21(2): 239-246【SCI收錄】
29. Xiaojuan Liu, Shun Shan Duan, Ai Fen Li, Kai Feng Sun. Effects of glycerol on the the fluorescence spectra and chloroplast ultrastructure of Phaeodactylum tricornum (Bacillariophyta). Journal of Integrative Plant Biology, 2009, 51(3): 272-278【SCI收錄】
30. Xiaojuan Liu, Fenglin He, Lichao Zhao, Aimei Zhou, Xin Liu*. Synergistic antioxidant activity of sweet potato extracts in combination with tea polyphenols and pueraria flavonoid in vitro. Advance Journal of Food Science and Technology, 6(2): 215-220, 2014【SCI收錄】
31. 張育昆,陳祉晴,張俊林,周樂松,林燕平,曹庸,劉曉娟*. 膳食類胡蘿卜素和脂溶性維生素的腸道吸收機制研究進展:重點關(guān)注轉(zhuǎn)運蛋白.食品科學, 2023(EI收錄)
32. 張俊林,陳祉晴,鄭欽生,肖杰,曹庸,劉曉娟*. 基于分子對接和表面等離子共振技術(shù)研究蝦青素與跨膜轉(zhuǎn)運蛋白CD36的結(jié)合作用. 2023, 44(12): 102-107(EI收錄)
33. 何宛詩,鄭欽生,陳小艷,夏增慧,曹庸,劉曉娟*. 雨生紅球藻新型抗氧化肽的制備純化、鑒定篩選及其對秀麗線蟲抗氧化能力的影響. 食品科學,2023(EI收錄)
34. 劉涵,張苗,劉曉娟*,曹 庸. 雨生紅球藻多糖的分離純化和免疫活性研究, 食品科學, 2019, 40(2): 52-58(EI收錄)
35. 劉涵, 陳曉楓, 劉曉娟*,賀麗蘋, 曹庸. 不同幾何構(gòu)型蝦青素的體外抗氧化及對秀麗線蟲氧化應(yīng)激的保護作用. 食品科學, 2019, 40(3): 178-185(EI收錄)
36. 姚康飛,張瑞蓮, 劉曉娟*, 曹庸, 趙力超, 賀麗蘋. 不同立體構(gòu)型蝦青素抗脂質(zhì)過氧化活性研究. 中國食品學報, 2018, 18(10): 86-94(EI收錄)
37. 袁曦,劉曉娟*,曹庸. 賦形劑乳液粒徑和菠菜加工方式對菠菜中β-胡蘿卜素生物可給性的影響. 食品科學,2019, 40(21): 78-87(EI收錄)
38. 張瑞蓮,劉曉娟*,張苗,熊平,陳雪香,曹庸 利用兔離體腸模型研究山莓葉的抗腹瀉作用機理 現(xiàn)代食品科技,2015,31(8): 18-24(EI收錄)
39. 常云佩, 劉曉娟*, 周麗萍, 熊平, 陳雪香, 曹庸. 山莓葉抑制兔離體腸運動活性物質(zhì)的提取及活性穩(wěn)定性研究. 現(xiàn)代食品科技, 2014, 30(4): 85-92(EI收錄)
40. 劉曉娟,何鳳林,趙力超,劉欣 番薯提取液與茶多酚、葛根黃酮對PC12細胞的協(xié)同抗氧化研究. 現(xiàn)代食品科技,發(fā)表時間:2015, 31(12): 14-18(EI收錄)
41. 劉曉娟, 龔麗, 毛新, 趙力超, 周愛梅, 劉欣*. 高溫短時氣流膨化薏米工藝優(yōu)化. 農(nóng)業(yè)工程學報, 2012, 28(15): 258-263(EI收錄)
相關(guān)知識
劉曉慶
劉曉紅:劉曉慶結(jié)婚純屬造謠
劉曉慶寫真
劉曉慶現(xiàn)在結(jié)婚了嗎,劉曉慶年齡多大
劉曉慶死了嗎
劉曉慶大婚丈夫系黃埔后代 劉曉慶四任老公
劉曉慶真實年齡
劉曉慶承認“四婚”
劉曉慶養(yǎng)生之道
劉曉慶是怎么保養(yǎng)的 學劉曉慶做不老妖精
網(wǎng)址: 劉曉娟 http://m.u1s5d6.cn/newsview1309900.html
推薦資訊
- 1發(fā)朋友圈對老公徹底失望的心情 12775
- 2BMI體重指數(shù)計算公式是什么 11235
- 3補腎吃什么 補腎最佳食物推薦 11199
- 4性生活姿勢有哪些 盤點夫妻性 10425
- 5BMI正常值范圍一般是多少? 10137
- 6在線基礎(chǔ)代謝率(BMR)計算 9652
- 7一邊做飯一邊躁狂怎么辦 9138
- 8從出汗看健康 出汗透露你的健 9063
- 9早上怎么喝水最健康? 8613
- 10五大原因危害女性健康 如何保 7826