石莉紅，1979年生，籍貫陜西渭南，干細(xì)胞生物學(xué)家，血研所研究員，博士生導(dǎo)師。1998年考入陜西師范大學(xué)生物學(xué)專業(yè)，2002年獲得學(xué)士學(xué)位。2003年在中國科學(xué)院動(dòng)物研究所生理學(xué)專業(yè)攻讀博士學(xué)位，從事生殖與發(fā)育研究。2008年進(jìn)入密歇根大學(xué)醫(yī)學(xué)院進(jìn)行博士后研究工作，主要研究生理病理紅系分化。 2014年晉升為研究員。

主要研究方向?yàn)槿松砑安±碓煅V系分化命運(yùn)決定的調(diào)控機(jī)制。開創(chuàng)性的將紅系與巨核譜系分化細(xì)胞命運(yùn)、異質(zhì)性亞群與血液疾病關(guān)聯(lián)起來，闡明疾病的發(fā)病機(jī)制，解答困擾領(lǐng)域多年的“未解之謎”。

1. Changlu Xu#, Jian He#, Hongtao Wang#, Yingnan Zhang#, Jing Wu#, Lu Zhao#, Yue Li, Jie Gao, Guangfeng Geng, Bingrui Wang, Xiaoyuan Chen, Zhaofeng Zheng, Biao Shen, Yang Zeng, Zhijie Bai, Hua Yang, Shujuan Shi, Fang Dong, Shihui Ma, Erlie Jiang, Tao Cheng, Yu Lan*, Jiaxi Zhou*, Bing Liu* and Lihong Shi*. Single-cell transcriptomic analysis identifies an immune-prone population in erythroid precursors during human ontogenesis. Nature Immunology, 2022 Jun 27. (IF=31.250)

2. Bingrui Wang#, Chenchen Wang#, Yang Wan#, Jie Gao#, Yige Ma, Yingnan Zhang, Jingyuan Tong, Yingchi Zhang, Jinhua Liu, Lixian Chang, Changlu Xu, Biao Shen, Yumei Chen, Erlie Jiang, Ryo Kurita, Yukio Nakamura, Kim-Chew Lim, James Douglas Engel, Jiaxi Zhou, Tao Cheng*, Xiaofan Zhu*, Ping Zhu* and Lihong Shi*. Decoding the pathogenesis of Diamond–Blackfan anemia using single-cell RNA-seq. Cell Discovery, 2022 May 10;8(1):41. (IF=38.079)

3.Yuechen Luo #, Changlu Xu #, Bing Wang #, Qing Niu #, Xiuhua Su #, Yingnan Bai, Shuxian Zhu, Chunxiao Zhao, Yunyan Sun, Jiali Wang, Maolan Liu, Xiaolei Sun, Ge Song, Haidong Cui, Xiaoli Chen, Huifang Huang, Haikun Wang, Mingzhe Han*, Erlie Jiang*, Lihong Shi*, Xiaoming Feng*. Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment. Nature Communications. 2021 Jun 23;12(1):3913. (IF=17.694)

4. Guangfeng Geng, Jinhua Liu, Changlu Xu, Yandong Pei, Linbo Chen, Chenglong Mu, Ding Wang, Jie Gao, Yue Li, Jing Liang, Tian Zhao, Chuanmei Zhang, Jiaxi Zhou, Quan Chen*, Yushan Zhu*, Lihong Shi* Receptor-mediated mitophagy regulates EPO production and protects against renal anemia. Elife 2021 10, e64480. (IF=8.713)

5.Yanni Ma#, Siqi Liu#, Jie Gao#, Chunyan Chen#, Xin Zhang#, Hao Yuan, Zhongyang Chen, Xiaolin Yin, Chenguang Sun, Yanan Mao, Fanqi Zhou, Yi Shao, Qian Liu, Jiayue Xu, Li Cheng, Daqi Yu, Pingping Li,Ping Yi, Jiahuan He, Guangfeng Geng, Qing Guo, Yanmin Si, Hualu Zhao, Haipeng Li, Graham L. Banes, He Liu, Yukio Nakamura, Ryo Kurita, Yue Huang, Xiaoshuang Wang, Fang Wang, Gang Fang, James Douglas Engel, Lihong Shi,* Yong E. Zhang,* and Jia Yu*.Genome-wide analysis of pseudogenes reveals HBBP1’s human-specific essentiality in erythropoiesis and implication in b-thalassemia. Developmental Cell. 2021, Feb 22; 56(4):478-493. (IF=13.417)

6. Jingyuan Tong#, Ting Sun#, Shihui Ma#, Yanhong Zhao#, Mankai Ju#, Yuchen Gao, Ping Zhu, Puwen Tan, Rongfeng Fu, Anqi Zhang, Ding Wang, Di Wang, Zhijian Xiao, Jiaxi Zhou, Renchi Yang, Stephen J. Loughran, Juan Li, Anthony R. Green, Emery H. Bresnick, Dong Wang,* Tao Cheng,*Lei Zhang,* and Lihong Shi* Hematopoietic Stem Cell Heterogeneity Is Linked to the Initiation and Therapeutic Response of Myeloproliferative Neoplasms, Cell Stem Cell, 2021, 28(3): 502–513. (IF=25.269)

7. Hongtao Wang#, Jian He#, Changlu Xu#, Xiaoyuan Chen#, Hua Yang#, Shujuan Shi, Cuicui Liu, Yang Zeng, Dan Wu, Zhijie Bai, Mengge Wang, Yuqi Wen, Pei Su, Meijuan Xia, Baiming Huang, Chunyu Ma, Lihong Bian, Yu Lan, Tao Cheng, Lihong Shi,* Bing Liu,* and Jiaxi Zhou*. Decoding Human Megakaryocyte Development. Cell Stem Cell. 2021, 28(3): 535-549.e8. (IF=25.269, F1000)

8. Yapu Li#, Ding Wang#, Hongtao Wang#, Xin Huang, Yuqi Wen, BingRui Wang, Changlu Xu,Jie Gao, Jinhua Liu, Jingyuan Tong, Mengge Wang, Pei Su, Sirui Ren, Feng Ma, Hong-Dong Li, Emery H Bresnick, Jiaxi Zhou,* & Lihong Shi,* A splicing factor switch controls hematopoietic lineage specification of pluripotent stem cells. EMBO Reports. 2021 Jan 7;22(1):e50535. (IF=9.071)

9. Jinhua Liu#, Yapu Li#, Jingyuan Tong#, Jie Gao, Qing Guo, Lingling Zhang, Bingrui Wang, Hui Zhao, Hongtao Wang, Erlie Jiang, Ryo Kurita, Yukio Nakamura, Osamu Tanabe, James Douglas Engel, Emery H. Bresnick, Jiaxi Zhou* & Lihong Shi*. Long non-coding RNA-dependent mechanism to regulate heme biosynthesis and erythrocyte development. Nature Communications. 2018 Oct 22;9(1):4386. (IF=17.694)

10. Lihong Shi#, Shuaiying Cui , James Douglas Engel, Osamu Tanabe*. Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction. Nature medicine, 2013, 19(3): 291-294. (IF=87.241)

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