低T4血癥：調(diào)查 妊娠期母親單純低甲狀腺素血癥 FT4＜10.4~12 低T4血癥：調(diào)查 FT4＜10.7 低T4血癥：調(diào)查 HenrichsJ：JCEM 2010， 95：4227-4234 Nonverbal : 非言語；cognitive : 認知 非言語認知能力遲滯是對照組的1～2倍 低T4血癥：調(diào)查 Pop VJ：Clin Endocrinol （Oxf）2003，59：282-288 Mental : 智力；motor : 運動 與正常對照，甲減者智力和運動能力隨時間↓ * # Compared to control group* p=0.004；# p=0.007 分 組 No. PDI X±SD MDI X±SD 低T4血癥 19 112.32±15.10* 112.21±12.26# 正常對照組 38 121.61±7.94 119.78±7.76 Li YB ,Shan ZY：Clin Endocrino;(oxf), 2010. 72(6):825-829. 低T4血癥：調(diào)查 妊娠16-20周孕婦單純低T4血癥與后代PDI和MDI (智力發(fā)育指數(shù)) (精神運動發(fā)育指數(shù)) ↓ ↓ 五、妊娠甲狀腺抗體陽性 Figure?1.?The TAZ10 transgenic mouse model10 and the immunological basis for Hashimoto thyroiditis.(a) Thyroid follicle and the location of the major thyroid autoantigens: thyroid peroxidase (TPO), thyroglobulin (Tg) and the thyroid-stimulating hormone receptor (TSHR). (b) Immunological mechanisms leading to the spectrum of human autoimmunity with differing pathological and clinical characteristics. Graves hyperthyroidism is caused directly by TSHR autoantibodies that activate the TSHR. Hypothyroidism in Hashimoto thyroiditis is associated with autoantibodies to TPO (and less commonly to Tg), but the relative contributions to thyrocyte damage by autoantibodies, TPO-specific T cells and/or cytokines is unknown.. he TAZ10 model of Quaratino et al. shows that TPO-specific T cells are sufficient to induce the histopathological and clinical features of Hashimoto disease. However, how CD8+ T cells and cytokines secreted by CD4+ T cells contribute to destruction has yet to be determined. T3, triiodothyronine. 甲狀腺過氧化物酶抗體 (thyroid peroxidase antibody, TPOAb) :TPO是一種糖基化血紅蛋白,跨于甲狀腺細胞頂緣細胞膜上, 伸向濾泡部分具有催化活性, 直接參與甲狀腺細胞中碘氧化 / 酪氨酸化及碘化酪氨酸偶聯(lián)等, 是甲狀腺素合成、分泌的關(guān)鍵酶由TPO所誘導(dǎo)產(chǎn)生的抗體即 TPOAb Pearce EN, Farwell AP, Braverman LE. Thyroiditis. N Engl J Med 2003;348:2646-2655. TSH參考值：試劑的影響 * 所有妊娠時點和產(chǎn)前兩種試劑檢測值存在統(tǒng)計學(xué)差異（P0.001），試劑差異！ ? N TSH (Abbott) TSH (Roche) 2.5th 5th 50th 95th 97.5th 2.5th 5th 50th 95th 97.5th 孕12周 140 0.03 0.07 0.91 3.38 3.60 0.05 0.11 1.48 4.40

相關(guān)知識

妊娠期甲狀腺功能異常的診療現(xiàn)狀
甲亢合并妊娠指南
【科普】孕產(chǎn)期甲狀腺疾病，重在預(yù)防！
妊娠期能否使用二甲雙胍？2022版《妊娠期高血糖診治指南》發(fā)布！
甲狀腺癌是“懶癌”？ 甲狀腺疾病要早發(fā)現(xiàn)早診斷早治療
妊娠蛋白尿就診指南
妊娠期鐵缺乏和缺鐵性貧血診治指南 （推薦條款）
妊娠期高血壓就診指南
2021年妊娠期糖尿病相關(guān)診療指南解讀
【妊娠期糖尿病癥狀】妊娠期糖尿病癥狀

網(wǎng)址: 妊娠和產(chǎn)后甲狀腺疾病診治指南 http://m.u1s5d6.cn/newsview186820.html