摘要: 維持免疫系統(tǒng)健康是有效的抗感染手段之一。實踐證明，除疫苗接種、藥物治療及非藥物干預之外，膳食營養(yǎng)及心理健康也是維持免疫系統(tǒng)健康，抗擊新發(fā)和突發(fā)感染的關鍵因素。維生素作為主要膳食營養(yǎng)素，是免疫應答的調節(jié)因子，對人體免疫力的影響至關重要。缺乏維生素會引起體內炎癥水平增加，免疫力降低等情況，往往最先發(fā)生在口腔組織。補充適當?shù)木S生素可以幫助機體改善免疫功能，增強口腔免疫，降低病原體感染對機體的影響，這是一種可行性和有效性皆具的通用抗感染方案。本文重點綜述了維生素A、B、C、D和E的免疫調節(jié)作用，為突破傳統(tǒng)單因子單通路的研究局限，利用組學研究進行全方位的維生素免疫調控及抗感染的基礎和應用研究提供方向。

關鍵詞: 維生素  /  免疫力  /  感染  

Abstract: Keeping the immune system healthy forms an effective way to fight infections. Past experience has shown that, in addition to effective interventions including vaccination, drug therapy, and non-pharmaceutical intervention (NPI), dietary nutrition and mental health are also key factors in maintaining immune system health and combating emerging and sudden outbreaks of infections. As the main dietary nutrients, vitamins are active regulators of the immune response and exert a critical impact on the immunity of the human body. Vitamin deficiency causes increased levels of inflammation and decreased immunity, which usually starts in the oral tissues. Appropriate vitamin supplementation can help the body optimize immune function, enhance oral immunity, and reduce the negative impact of pathogen infection on the human body, which makes it a feasible, effective, and universally applicable anti-infection solution. This review focuses on the immunomodulatory effects of vitamin A, B, C, D, and E and proposes that an omics-based new systemic approach will lead to a breakthrough of the limitations in traditional single-factor single-pathway research and provide the direction for the basic and applied research of vitamin immune regulation and anti-infection in all aspects.

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