摘要: 應激是生物體對外源或內源刺激的一種非特異的適應性反應，有助于維持機體的內環(huán)境穩(wěn)態(tài)和正常的生理活動。當應激反應的程度超過了機體的適應能力時，會誘發(fā)多種生理或心理疾病。應激醫(yī)學以應激反應誘發(fā)的各種疾病為研究對象，闡釋應激狀態(tài)下的生理、病理過程及應激損傷機制，并探索應激相關疾病的預防和治療手段。本文將從應激反應的概念入手，總結近年來關于應激反應在多種生理或病理狀態(tài)下的調控機制和生物學功能的研究結果，探討應激醫(yī)學最新研究進展。

Abstract: Stress is an nonspecific adaptive response to endogenous or exogenous stimuli, which is commonly applied by organisms to maintain their internal homeostasis and normal physiological functions. When the extent of stress response surpasses the threshold that the organism can adjust to, a variety of physiological or psychological diseases can be induced by stress response. Stress medicine focuses on investigating the mechanisms underlying the development and progression of the diseases induced by stress response, aiming to find ways to prevent and treat stress-related diseases. Here, we will start with an introduction of stress response, then review the recent advances of stress medicine by discussing the latest research advances in the regulatory mechanisms and biological functions of stress response under various physiological or pathological conditions.

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