Authors:Zixiang Wang, Yinghao Zhu, Huiya Zhao, Xiaochen Zheng, Dehao Sui, Tianlong Wang, Wen Tang, Yasha Wang, Ewen Harrison, Chengwei Pan, Junyi Gao, Liantao Ma

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Abstract:We introduce ColaCare, a framework that enhances Electronic Health Record (EHR) modeling through multi-agent collaboration driven by Large Language Models (LLMs). Our approach seamlessly integrates domain-specific expert models with LLMs to bridge the gap between structured EHR data and text-based reasoning. Inspired by the Multidisciplinary Team (MDT) approach used in clinical settings, ColaCare employs two types of agents: DoctorAgents and a MetaAgent, which collaboratively analyze patient data. Expert models process and generate predictions from numerical EHR data, while LLM agents produce reasoning references and decision-making reports within the MDT-driven collaborative consultation framework. The MetaAgent orchestrates the discussion, facilitating consultations and evidence-based debates among DoctorAgents, simulating diverse expertise in clinical decision-making. We additionally incorporate the Merck Manual of Diagnosis and Therapy (MSD) medical guideline within a retrieval-augmented generation (RAG) module for medical evidence support, addressing the challenge of knowledge currency. Extensive experiments conducted on three EHR datasets demonstrate ColaCare's superior performance in clinical mortality outcome and readmission prediction tasks, underscoring its potential to revolutionize clinical decision support systems and advance personalized precision medicine. All code, case studies and a questionnaire are available at the project website: this https URL. Comments: ACM TheWebConf 2025 Conference (WWW 2025) Research Track Subjects: Machine Learning (cs.LG); Artificial Intelligence (cs.AI); Computation and Language (cs.CL) Cite as: arXiv:2410.02551 [cs.LG]   (or arXiv:2410.02551v2 [cs.LG] for this version)   https://doi.org/10.48550/arXiv.2410.02551

arXiv-issued DOI via DataCite

Related DOI: https://doi.org/10.1145/3696410.3714877

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Submission history

From: Yinghao Zhu [view email]
[v1] Thu, 3 Oct 2024 14:55:22 UTC (3,391 KB)
[v2] Wed, 26 Feb 2025 13:51:56 UTC (3,643 KB)

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