教育背景

博士 2015.09-2019.06 中國科學(xué)院大學(xué) 微生物

碩士 2009.11-2011.11 荷蘭瓦赫寧根大學(xué) 食品安全

學(xué)士 2005.09–2009.06 中國農(nóng)業(yè)大學(xué) 食品質(zhì)量與安全

工作經(jīng)歷

起止時(shí)間 單位名稱 專業(yè)技術(shù)職務(wù)

2025.01-至今 山東大學(xué)微生物改造技術(shù)研究院/全國重點(diǎn)實(shí)驗(yàn)室 教授

2022.08-2024.12 山東大學(xué)微生物技術(shù)研究院/國家重點(diǎn)實(shí)驗(yàn)室 研究員

2012.02-2022.07 中國科學(xué)院微生物研究所微生物資源前期開發(fā)國家重點(diǎn)實(shí)驗(yàn)室 助理實(shí)驗(yàn)師、助理研究員、副研究員

研究方向

1.腸道微生物培養(yǎng)組學(xué)

2.腸道新功能菌株發(fā)掘與機(jī)制研究

科研項(xiàng)目

1.2025.01-2027.12國家自然科學(xué)基金委優(yōu)秀青年基金項(xiàng)目“腸道微生物培養(yǎng)、功能與機(jī)制研究”，200萬元

2.2023.01-2025.12山東省泰山學(xué)者青年專家項(xiàng)目，75萬

3.2024.01-2026.12山東省優(yōu)青項(xiàng)目“腸道微生物資源收集及功能機(jī)制研究”，50萬

4.2022.01-2025.12國家自然科學(xué)基金面上項(xiàng)目“一株產(chǎn)新型細(xì)菌素腸球菌的抑菌機(jī)理及潛在應(yīng)用的基礎(chǔ)研究”，58萬元

5.2022.01-2026.12國家重點(diǎn)研發(fā)計(jì)劃“變革性技術(shù)關(guān)鍵科學(xué)問題”專項(xiàng)、“高通量培養(yǎng)篩選鑒定健康相關(guān)微生物的關(guān)鍵技術(shù)”項(xiàng)目、“微生物高通量培養(yǎng)與表征”課題，105萬元

6.2020.02-2024.12國家重點(diǎn)研發(fā)計(jì)劃“合成生物學(xué)”專項(xiàng)、“合成生物腸道菌群體系構(gòu)建及應(yīng)用”項(xiàng)目、“重要腸道微生物的合成生物學(xué)設(shè)計(jì)與功能強(qiáng)化”課題，118.4萬元

7.2022.12-2027.11國家重點(diǎn)研發(fā)計(jì)劃“生物大分子與微生物組”專項(xiàng)、“微生物組學(xué)新技術(shù)及相關(guān)實(shí)驗(yàn)動(dòng)物體系”項(xiàng)目、“菌群功能模塊定向培養(yǎng)和理性調(diào)控技術(shù)”課題，231萬元

8.2017.01-2019.12中科院重點(diǎn)部署項(xiàng)目，人體與環(huán)境健康的微生物組共性技術(shù)研究項(xiàng)目“非人靈長(zhǎng)類實(shí)驗(yàn)動(dòng)物模型腸道微生物菌株資源庫的構(gòu)建”課題，102萬元

代表性論文

(1)Liu, Chang; Du, Meng-Xuan; Xie, Li-Sheng; Wang, Wen-Zhao; Chen, Bao-Song; Yun, Chu-Yu; Sun, Xin-Wei; Luo, Xi; Jiang, Yu; Wang, Kai; Jiang, Min-Zhi; Qiao, Shan-Shan; Sun, Min; Cui, Bao-Juan; Huang, Hao-Jie; Qu, Shu-Ping; Jiang, Min-Zhi; Wu, Dalei; Wang, Lu-Shan; Jiang, Changtao*; Liu, Hong-Wei*; Liu, Shuang-Jiang*; Gut commensal Christensenella minuta modulates host metabolism via acylated secondary bile acids, NATURE MICROBIOLOGY, 2024;9(2):434-450

(2)Liu, Chang; Zhou, Nan; Du, Meng-Xuan; Sun, Yu-Tong; Wang, Kai; Wang, Yu-Jing; Li, Dan- Hua; Yu, Hai-Ying; Song, Yuqin; Bai, Bing-Bing; Xin, Yuhua; Wu, Linhuan; Jiang, Cheng-Ying; Feng, Jie; Xiang, Hua; Zhou, Yuguang; Ma, Juncai; Wang, Jun; Liu, Hong-Wei*; Liu, Shuang-Jiang*; The Mouse Gut Microbial Biobank expands the coverage of cultured bacteria, NATURE COMMUNICATIONS, 2020, 11(1): 79

(3)Liu, Chang#*; Du, Meng-Xuan#; Abuduaini, Rexiding#; Yu, Hai-Ying; Li, Dan-Hua; Wang, Yu-Jing; Zhou, Nan; Jiang, Min-Zhi; Niu, Peng-Xia; Han, Shan-Shan; Chen, Hong-He; Shi, Wen-Yu; Wu, Linhuan; Xin, Yu-Hua; Ma, Juncai; Zhou, Yuguang; Jiang, Cheng-Ying; Liu, Hong-Wei; Liu, Shuang- Jiang*; Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank, MICROBIOME, 2021, 9(1): 119

(4)Qiao, Shan-Shan#;Liu, Chang#; Sun, Li; Wang, Tao; Dai, Huan-Qin; Wang, Kai; Bao, Li; Li, Han-Tian; Wang, Wen-Zhao; Liu, Shuang-Jiang*; Liu, Hong-Wei*; Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism, Nature Metabolism, 2022, 4(10): 1271-1286

(5)Abdugheni, Rashidin; Wang, Wen‐Zhao; Wang, Yu‐Jing; Du, Meng‐Xuan; Liu, Feng‐Lan; Zhou, Nan; Jiang, Cheng‐Ying; Wang, Chang‐Yu; Wu, Lin-Huan; Ma, Jun-Cai;Liu, Chang*; Liu, Shuang‐Jiang*; Metabolite profiling of human‐originated Lachnospiraceae at the strain level, iMeta, 2022, 1(4): e58

(6)Jiang, Yu; Du, Meng-Xuan; Xie, Li-Sheng; Jiang, Min-Zhi; Zhang, Yao-Kun; Bi, Ming-Xia;Liu, Chang*; Liu, Hong-Wei; Liu, Shuang-Jiang*; The human-derived novel gut commensal Luoshenia tenuis regulates body weight and food intake in mice, Food Science and Human Wellness, 2022

(7)Li, Dan-Hua#;Liu, Chang#; Abuduaini, Rexiding; Du, Meng-Xuan; Wang, Yu-Jing; Zhu, Hai- Zhen; Chen, Hong-He; Zhou, Nan; Xin, Yu-Hua; Wu, Lin-Huan; Ma, Jun-Cai; Zhou, Yu-Guang; Lu, Yong; Jiang, Cheng-Ying; Sun, Qiang*; Liu, Shuang-Jiang*; The monkey microbial biobank brings previously uncultivated bioresources for nonhuman primate and human gut microbiomes, mLife, 2022, 1(2): 210- 217

(8)Qiao, Shan-Shan#; Wang, Kai#;Liu, Chang#; Zhou, Nan; Bao, Li; Wang, Jun; Liu, Shuang-Jiang; Liu Hong-Wei; The enriched gut commensal Faeciroseburia intestinalis contributes to the anti- metabolic disorders effects of the Ganoderma meroterpene derivative, Food Science and Human Wellness, 2022, 11(1): 85-96

(9)Li, Dan-Hua; Abuduaini, Rexiding; Du, Meng-Xuan; Wang, Yu-Jing; Chen, Hong-He; Zhou, Nan; Zhu, Hai-Zhen; Lu, Yong; Yu, Pei-Jun; Yang, Yun-Peng; Jiang, Cheng-Ying; Sun, Qiang;Liu, Chang*; Liu, Shuang-Jiang*; Alkaliphilus flagellatus sp. nov., Butyricicoccus intestinisimiae sp. nov., Clostridium mobile sp. nov., Clostridium simiarum sp. nov., Dysosmobacter acutus sp. nov., Paenibacillus brevis sp. nov., Peptoniphilus ovalis sp. nov. and Tissierella simiarum sp. nov., isolated from monkey faeces, International Journal of Systematic and Evolutionary Microbiology, 2022, 72(3)

(10)Liu, Chang; Zhang, Bo; Liu, Yi-Ming; Yang, Ke-Qian; Liu, Shuang-Jiang*; New Intracellular Shikimic Acid Biosensor for Monitoring Shikimate Synthesis in Corynebacterium glutamicum, ACS Synthetic Biology, 2018, 7(2): 591-601

(11)Liu, Chang; Liu, Yi-Ming; Sun, Qing-Lan; Jiang, Cheng-Ying; Liu, Shuang-Jiang*; Unraveling the kinetic diversity of microbial 3-dehydroquinate dehydratases of shikimate pathway, AMB EXPRESS, 2015, 5(7): 7-7

所獲專利

(1)劉雙江;劉暢;杜夢(mèng)璇;周楠;姜成英;一種藥物候選物對(duì)于腸道菌群作用效果的體外高通量篩選平臺(tái), 2020-3-17,中國, 202010186816.3

(2)劉雙江;劉暢;周楠;姜成英;杜夢(mèng)璇;膽酸衍生物及其應(yīng)用, 2022-2-22,中國, 202210160201.2

(3)劉雙江;劉暢;杜夢(mèng)璇;周楠;姜成英;一株小克里斯滕森氏菌SJ-2及其應(yīng)用, 2021-5-17,中國, 2021105334244.1

(4)劉雙江;劉暢;周楠;姜成英;杜夢(mèng)璇;膽酸衍生物及其制備, 2022-2-22,中國, 202210160175.3

(5)劉宏偉;劉雙江;劉暢;喬珊珊;代煥琴;韓俊杰;孫敬祖;糞副擬桿菌以及應(yīng)用, 2021-7-12,中國, 202110786071.9

(6)劉宏偉;劉雙江;喬珊珊;劉暢;羅氏菌MGB-2及其應(yīng)用, 2021-2-22,中國, 202110176582.9

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