摘要: 乳酸菌類益生菌是功能性食品的主要生理活性成分之一,其益生作用已經(jīng)成為食品科學(xué)和臨床醫(yī)學(xué)領(lǐng)域的研究熱點(diǎn)。本文就近年來乳酸菌改善乳糖不耐癥、防治腹瀉和消化性潰瘍、提高機(jī)體免疫力等益生功能和作用機(jī)制的研究進(jìn)展做一綜述,并對(duì)研究前景提出展望,以期為我國乳酸菌的開發(fā)應(yīng)用奠定基礎(chǔ)。 

關(guān)鍵詞: 乳酸菌  /  益生菌  /  益生功能  /  作用機(jī)制  

Abstract: Lactic acid bacteria was one of physiological active components in functional foods. Its probiotic actions have been paid much attention in the field of food science and clinical medicine. The research progress on the probiotic potential and mechanism of action,including alleviating of lactose intolerance,preventing and treating of diarrhea and ulcers,enhancing of host's immune response were reviewed in this article,and brought forward the prospect of research with a view to laying the foundation on the development and application of Lactic acid bacteria in our country.

[1]

Malaguarnera G,Leggio F,Vacante M,et al.Probiotics in the gastrointestinal diseases of the elderly[J].The Journal of Nutrition,Health&Aging,2012,16(4):402-410.

[2]

Chassard C,Dapoigny M,Scott K P,et al.Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome[J].Alimentary Pharmacology&Therapeutics,2012,35(7):828-838.

[3]

Gareau M G,Sherman P M,Walker W A.Probiotics and the gut microbiota in intestinal health and disease[J].Nature Reviews Gastroenterology and Hepatology,2010,7(9):503-514.

[4]

Sekirov I,Russell S L,Antunes L C M,et al.Gut microbiota in health and disease[J].Physiological Reviews,2010,90(3):859-904.

[5] 烏斯?jié)M,依米提,阿迪拉,等.具有高效抑菌活性的腸道乳酸菌的篩選[J].食品工業(yè)科技,2012,33(24):210-214. [6]

Galdeano C M,De Leblanc A de M,Carmuega E,et al.Mechanisms involved in the immunostimulation by probiotic fermented milk[J].Journal of Dairy Research,2009,76(4):446-454.

[7] 劉少敏,滿朝新,李理,等.乳酸菌免疫調(diào)節(jié)作用的研究進(jìn)展[J].中國食物與營養(yǎng),2013,19(4):60-63. [8]

Widyastuti Y,Febrisiantosa A.The role of lactic acid bacteria in milk fermentation[J].Food and Nutrition Sciences,2014,5(4):435-442.

[9]

Liu S,Han Y,Zhou Z.Lactic acid bacteria in traditional fermented Chinese foods[J].Food Research International,2011,44(3):643-651.

[10]

Rhee S J,Lee J E,Lee C H.Importance of lactic acid bacteria in Asian fermented foods[J].Microbial Cell Factories,2011,10(suppl 1):S5.

[11] 桑尼.了解乳酸菌[J].人人健康,2013(20):26-27. [12]

Pradeep K,Kuttappa M A,Prasana K R.Probiotics and oral health:an update[J].South African Dental Journal,2014,69(1):20-24.

[13]

Rabot S,Rafter J,Rijkers G T,et al.Guidance for substantiating the evidence for beneficial effects of probiotics:impact of probiotics on digestive system metabolism[J].The Journal of Nutrition,2010,140(3):677S-689S.

[14]

Lomer M C E,Parkes G C,Sanderson J D.Review article:lactose intolerance in clinical practice-myths and realities[J].Alimentary Pharmacology&Therapeutics,2008,27(2):93-103.

[15] 顏紀(jì)賢,李明岳,鐘景耀,等.正常成年人對(duì)牛奶和酸牛奶中乳糖吸收程度和不耐受程度的調(diào)查[J].營養(yǎng)學(xué)報(bào),1987,9(20):22-24. [16] 谷月華,張京聲,安浩然,等.高產(chǎn)β-半乳糖苷酶植物乳桿菌的篩選及其酶學(xué)性質(zhì)研究[J].中國乳品工業(yè),2012,40(9):8-10. [17] 宋園亮,李海燕,柳陳堅(jiān).乳酸菌治療乳糖不耐受癥的研究進(jìn)展[J].中國微生態(tài)學(xué)雜志,2010(8):751-753. [18]

Vincent V,Aghajari N,Pollet N,et al.The acid tolerant and cold-activeβ-galactosidase from Lactococcus lactis strain is an attractive biocatalyst for lactose hydrolysis[J].Antonie Van Leeuwenhoek,2013,103(4):701-712.

[19]

Li J,Zhang W,Wang C,et al.Lactococcus lactis expressing food-gradeβ-galactosidase alleviates lactose intolerance symptoms in post-weaning Balb/c mice[J].Applied Microbiology and Biotechnology,2012,96(6):1499-1506.

[20] 陳青.雙歧桿菌及酪酸梭菌聯(lián)合治療嬰兒繼發(fā)性乳糖不耐受72例[J].天津醫(yī)藥,2007,35(3):237. [21]

Kolars JC,Levitt MD,Aouji M,et al.Yogurt--an autodigesting source of lactose[J].The New England Journal of Medicine,1984,310(1):1-3.

[22]

Pochart P,Dewit O,Desjeux JF,et al.Viable starter culture,beta-galactosidase activity,and lactose in duodenum after yogurt ingestion in lactase-deficient humans[J].The American Journal of Clinical Nutrition,1989,49(5):828-831.

[23]

Savaiano DA.Lactose digestion from yogurt:mechanism and relevance[J].The American Journal of Clinical Nutrition,2014,99(5 Suppl):1251S-12555S.

[24]

Preidis G A,Hill C,Guerrant R L,et al.Probiotics,enteric and diarrheal diseases,and global health[J].Gastroenterology,2011,140(1):8-14.

[25]

De Vrese M,Marteau P R.Probiotics and prebiotics:effects on diarrhea[J].The Journal of Nutrition,2007,137(3):803S-811S.

[26]

Weizman Z,Asli G,Alsheikh A.Effect of a probiotic infant formula on infections in child care centers:comparison of two probiotic agents[J].Pediatrics,2005,115(1):5-9.

[27]

Canani R B,Cirillo P,Terrin G,et al.Probiotics for treatment of acute diarrhoea in children:randomised clinical trial of five different preparations[J].British Medical Journal,2007,335(7615):335-340.

[28]

Guandalini S.Probiotics for prevention and treatment of diarrhea[J].Journal of Clinical Gastroenterology,2011,45:S149-S153.

[29]

Benno Y,He F,Hosada M,et al.Effects of Lactobacillus GGyoghurt on human intestinal microecology in Japanese subjects[J].Nutrition Today,1996,31(6 suppl):9-11S.

[30]

Apostolidis E,Kwon Y I,Shinde R,et al.Inhibition of Helicobacter pylori by fermented milk and soymilk using select lactic acid bacteria and link to enrichment of lactic acid and phenolic content[J].Food Biotechnology,2011,25(1):58-76.

[31] 周方方,吳正鈞,王蔭榆,等.數(shù)學(xué)模型法研究L.casei LC2W對(duì)H.pylori SS1黏附MKN-45細(xì)胞的抑制作用[J].中國微生態(tài)學(xué)雜志,2009,20(6):558-561. [32]

Lee J S,Paek N S,Kwon O S,et al.Anti-inflammatory actions of probiotics through activating suppressor of cytokine signaling(SOCS)expression and signaling in Helicobacter pylori infection:A novel mechanism[J].Journal of Gastroenterology and Hepatology,2010,25(1):194-202.

[33]

Fujimura S,Watanabe A,Kimura K,et al.Probiotic mechanism of Lactobacillus gasseri OLL2716 Strain against Helicobacter pylori[J].Journal of Clinical Microbiology,2012,50(3):1134-1136.

[34]

Lam E K Y,Tai E K K,Koo M W L,et al.Enhancement of gastric mucosal integrity by Lactobacillus rhamnosus GG[J].Life Sciences,2007,80(23):2128-2136.

[35]

Sˇusˇkovic'J,Kos B,Beganovic'J,et al.Antimicrobial activitythe most important property of probiotic and starter lactic acid bacteria[J].Food Technology and Biotechnology,2010,48(3):296-307.

[36]

Hsiao C P,Siebert K J.Modeling the inhibitory effects of organic acids on bacteria[J].International Journal of Food Microbiology,1999,47(3):189-201.

[37]

Pridmore R D,Pittet A C,Praplan F,et al.Hydrogen peroxide production by Lactobacillus johnsonii NCC 533 and its role in anti-Salmonella activity[J].FEMS Microbiology Letters,2008,283(2):210-215.

[38]

Cálix-Lara T F,Rajendran M,Talcott S T,et al.Inhibition of Escherichia coli O157∶H7 and Salmonella enteric on spinach and identification of antimicrobial substances produced by a commercial Lactic Acid Bacteria food safety intervention[J].Food Microbiology,2014,38:192-200.

[39]

Candela M,Perna F,Carnevali P,et al.Interaction of probiotic Lactobacillus and Bifidobacterium strains with human intestinal epithelial cells:adhesion properties,competition against enteropathogens and modulation of IL-8 production[J].International Journal of Food Microbiology,2008,125(3):286-292.

[40]

Neeser J R,Granato D,Rouvet M,et al.Lactobacillus johnsonii La1 shares carbohydrate-binding specificities with several enteropathogenic bacteria[J].Glycobiology,2000,10(11):1193-1199.

[41]

Dallal M M S,Yazdi M H,Hassan Z M.Lactobacillus casei ssp.casei Induced Th1 Cytokine Profile and Natural Killer Cells Activity in Invasive Ductal Carcinoma Bearing Mice[J].Iranian Journal of Allergy,Asthma and Immunology,2012,11(2):183-189.

[42]

Bleau C,Monges A,Rashidan K,et al.Intermediate chains of exopolysaccharides from Lactobacillus rhamnosus RW-9595Mincrease IL-10 production by macrophages[J].Journal of Applied Microbiology,2010,108(2):666-675.

[43]

Dong H,Rowland I,Yaqoob P.Comparative effects of six probiotic strains on immune function in vitro[J].British Journal of Nutrition,2012,108(3):459-470.

[44]

Elmadfa I,Klein P,Meyer A L.Immune-stimulating effects of lactic acid bacteria in vivo and in vitro[J].Proceedings of the Nutrition Society,2010,69(3):416-420.

[45]

Hiramatsu Y,Hosono A,Konno T,et al.Orally administered Bifidobacterium triggers immune responses following capture by CD11c(+)cells in Peyer’s patches and cecal patches[J].Cytotechnology,2011,63(3):307-317.

[46] 陳衛(wèi).乳酸菌-研究熱點(diǎn)、產(chǎn)業(yè)近況及發(fā)展趨勢[A].乳酸菌與營養(yǎng)健康:第九屆乳酸菌與健康國際研討會(huì)摘要匯編[C].2014. [47]

Guo L,Karpac J,Tran S L,et al.PGRP-SC2 promotes gut immune homeostasis to limit commensal dysbiosis and extend lifespan[J].Cell,2014,156(1-2):109-122.

[48] 周曉瑩,陳曉琳.乳酸菌的益生作用及其應(yīng)用研究進(jìn)展[J].中國微生態(tài)學(xué)雜志,2011,23(10):946-949. [49]

Kim H S,Park D W,Youn Y K,et al.Liver abscess and empyema due to Lactococcus lactis cremoris[J].Journal of Korean Medical Science,2010,25(11):1669-1671.

相關(guān)知識(shí)

益生菌的生理功能及作用機(jī)理研究進(jìn)展
益生乳酸菌與人體健康的研究進(jìn)展
潛在益生乳酸菌分離和鑒定研究進(jìn)展
果蔬膳食纖維生理功能及其作用機(jī)制研究進(jìn)展
益生菌治療乳糖不耐受的機(jī)制研究及臨床應(yīng)用前景分析
紅茶菌成分及功能研究進(jìn)展
低聚半乳糖對(duì)腸道益生菌作用機(jī)理的研究
探討發(fā)酵型乳酸菌的健康益處及其機(jī)制
乳鐵蛋白生理活性及作用機(jī)理研究進(jìn)展
益生菌與腸道健康的主要作用機(jī)制及益生菌在消化道疾病的應(yīng)用

網(wǎng)址: 乳酸菌的益生功能及作用機(jī)制研究進(jìn)展 http://m.u1s5d6.cn/newsview802666.html