Mycophenolic Acid 霉酚酸 細(xì)胞代謝抑制劑：霉酚酸（Mycophenolic Acid，MPA），又名麥可酚酸，是一種免疫抑制劑，用來預(yù)防器管移置后的排斥反應(yīng)。MPA還具有抗真菌、抗細(xì)菌、抗病毒和抗腫瘤效應(yīng)。

Mycophenolic Acid (MPA) 霉酚酸（麥可酚酸）

Mycophenolic Acid (MPA) 霉酚酸；Immunosuppressive Drug 免疫抑制劑；Inosine monophosphatase dehydrogenase次黃嘌呤單核苷酸脫氫酶；IMPDH Inhibitor; Mycophenolate mofetil 嗎替麥考酚酯；CAS NO：24280-93-1；

產(chǎn)品信息

MZ9231-0100MG

24280-93-1

100mg

霉酚酸（Mycophenolic Acid，MPA），又名麥可酚酸，是一種免疫抑制劑，用來預(yù)防器guan移植后的排斥反應(yīng)。MPA的功能在其是一種有效且可逆的次黃嘌呤單核苷酸脫氫酶（IMPDH）抑制劑，淋巴細(xì)胞中能阻斷GTP的從頭合成并引起RNA和DNA合成的減少，從而防止淋巴細(xì)胞增殖和活化，并抑制抗體生成。MPA還具有抗真菌、抗細(xì)菌、抗病毒和抗腫瘤效應(yīng)。

產(chǎn)品特性

1）   CAS NO：24280-93-1

2）   化學(xué)名：6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid

3）   同義名：MPA; NSC 129185;

4）   分子式：C17H20O6

5）   分子量：320.34

6）   純度：≥98%

7）   外觀：白色或類白色粉末

8）   溶解性：溶于乙醇、甲醇、DMSO（30mg/ml）、不溶于水

注意事項(xiàng)

1）   本霉酚酸（MPA）不是臨床藥物，只能用于科研用途，不能用于診斷或臨床用途。

2）   為了您的安全和健康，請(qǐng)穿實(shí)驗(yàn)服并戴一次性手套操作。

使用方法

體外研究：

細(xì)胞類型（Cell type）：Hepatocytes (from rat liver) in Primary Culture

藥物配制（Preparation）：MPA was dissolved in DMSO

實(shí)驗(yàn)方法（Assay）：MPA was dissolved in DMSO and added in the appropriate concentrations (0.6, 1.2, 2.4, 5, 10 μg/ml). The amount of DMSO added to the medium was never more than 2 μL/mL, which does not affect hepatocyte proliferation. The in vitro DNA synthesis was detected by [3H] Thymidine Incorporation.

體內(nèi)研究：

動(dòng)物模型（Animal Model）：70% partial hepatectomy rat model

藥物配制（Preparation）：MPA was dissolved in 0.5% carbossil-methil-cellulose (CMC), 0.4% Tween, and 0.9% alcohol in saline.

注射劑量（Dosages）：Rats were assigned to groups and treated for 4 days as controls or with MPA (15mg/kg). On the 4th day, between 0900 and 1030 hours, the rats received a standard 70% hepatectomy under light ether anesthesia. Food and drink were allowed immediay. Twenty-four hours after the hepatectomies, 185 × 10?4 Bq [3H] thymidine was administered to all rats by intraperitoneal injection.

給藥途徑（Administration）：Oral (p.o.)

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 Mycophenolic Acid 霉酚酸 細(xì)胞代謝抑制劑

Mycophenolic Acid 霉酚酸 細(xì)胞代謝抑制劑